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Neuromodulation of Thought: Flexibilities and Vulnerabilities in Prefrontal Cortical Network Synapses

• Amy F. T. Arnsten, Min Juan Wang, Constantinos D. Paspalas
• Neuron
• 2012

This review describes unique neuromodulatory influences on working memory prefrontal cortical (PFC) circuits that coordinate cognitive strength with arousal state. Working memory arises from… (More)

Dynamic Network Connectivity: A new form of neuroplasticity

• Amy F. T. Arnsten, Constantinos D. Paspalas, Nao J. Gamo, Yang Yang, Min Juan Wang
• Trends in Cognitive Sciences
• 2010

Prefrontal cortical (PFC) working memory functions depend on pyramidal cell networks that interconnect on dendritic spines. Recent research has revealed that the strength of PFC network connections… (More)

Nicotinic α7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex.

• Yang Yang, Constantinos D. Paspalas, Lu E. Jin, Marina R. Picciotto, Amy F. T. Arnsten, Min Juan Wang
• Proceedings of the National Academy of Sciences…
• 2013

The cognitive function of the highly evolved dorsolateral prefrontal cortex (dlPFC) is greatly influenced by arousal state, and is gravely afflicted in disorders such as schizophrenia, where there… (More)

Constellation of HCN channels and cAMP regulating proteins in dendritic spines of the primate prefrontal cortex: potential substrate for working memory deficits in schizophrenia.

• Constantinos D. Paspalas, Min Juan Wang, Amy F. T. Arnsten
• Cerebral cortex
• 2013

Schizophrenia associates with impaired prefrontal cortical (PFC) function and alterations in cyclic AMP (cAMP) signaling pathways. These include genetic insults to disrupted-in-schizophrenia (DISC1)… (More)

Stress Impairs Prefrontal Cortical Function via D<ce:inf loc=post>1</ce:inf> Dopamine Receptor Interactions With Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels

• Nao J. Gamo, Gyorgy Lur, +12 authors Amy F. T. Arnsten
• Biological Psychiatry
• 2015

BACKGROUND Psychiatric disorders such as schizophrenia are worsened by stress, and working memory deficits are often a central feature of illness. Working memory is mediated by the persistent firing… (More)

Targeting Prefrontal Cortical Systems for Drug Development: Potential Therapies for Cognitive Disorders.

• Amy F. T. Arnsten, Min Juan Wang
• Annual review of pharmacology and toxicology
• 2016

Medications to treat cognitive disorders are increasingly needed, yet researchers have had few successes in this challenging arena. Cognitive abilities in primates arise from highly evolved… (More)

Dopamine's Actions in Primate Prefrontal Cortex: Challenges for Treating Cognitive Disorders.

• Amy F. T. Arnsten, Min Juan Wang, Constantinos D. Paspalas
• Pharmacological reviews
• 2015

The prefrontal cortex (PFC) elaborates and differentiates in primates, and there is a corresponding elaboration in cortical dopamine (DA). DA cells that fire to both aversive and rewarding stimuli… (More)

Nicotinic α4β2 Cholinergic Receptor Influences on Dorsolateral Prefrontal Cortical Neuronal Firing during a Working Memory Task.

• Yongan Sun, Yang Yang, Veronica C Galvin, Shengtao Yang, Amy F. T. Arnsten, Min Juan Wang
• The Journal of neuroscience : the official…
• 2017

The primate dorsolateral prefrontal cortex (dlPFC) subserves top-down regulation of attention and working memory abilities. Depletion studies show that the neuromodulator acetylcholine (ACh) is… (More)

Why and How Traffic Safety Cultures Matter when Designing Advisory Traffic Information Systems

• Min Juan Wang, Sus Lundgren Lyckvi, Fang Chen
• CHI
• 2016

With an increased number of both cars and drivers in the world, it is of great importance to design well-functioning driver support systems for them, in order to reduce the number of accidents.… (More)

mGluR2 versus mGluR3 Metabotropic Glutamate Receptors in Primate Dorsolateral Prefrontal Cortex: Postsynaptic mGluR3 Strengthen Working Memory Networks.

• Lu E. Jin, Min Juan Wang, +4 authors Constantinos D. Paspalas
• Cerebral cortex
• 2018

The newly evolved circuits in layer III of primate dorsolateral prefrontal cortex (dlPFC) generate the neural representations that subserve working memory. These circuits are weakened by increased… (More)

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