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By integrating convergent protein engineering and rational inhibitor design, we have developed an in vivo conditional protein knockout andor manipulation technology. This method is based on the creation of a specific interaction interface between a modified protein domain and sensitized inhibitors. By introducing this system into genetically modified mice,(More)
Although the functions of alpha-Ca(2+)/calmodulin-dependent kinase II (CaMKII) have been studied extensively, the role of betaCaMKII, a coconstituent of the CaMKII holoenzyme in synaptic plasticity, learning, and memory has not been examined in vivo. Here we produce a transgenic mouse line in which the inducible and reversible manipulation of betaCaMKII(More)
In a ferromagnetic material, the relaxation of the magnetization distribution is described by Landau-Lifshitz-Gilbert (LLG) equation. In this study, the LLG equation is numerically solved with the Successive Over Relaxation method, which has the enhanced stability and accuracy compared to the Gauss-Seidel approaches. The numerical example for an(More)
A Boundary Integral Equation for the eigenmode of Photonic Crystal Fibers is formulated and numerically solved using the Nyström method. The real and imaginary parts of the propagation constant, which are related to the dispersion and the confinement loss of fibers, are obtained using a secant method. This formulation is very flexible to handle the fiber(More)
a r t i c l e i n f o a b s t r a c t The rigorous coupled-wave analysis method with Airy-like Internal-Reflection Series for the polar gyrotropic grating is improved with the Fourier factorization rule. In the process of derivation, Maxwell's equation is reformulated in order to avoid type 3 product and, either Laurent's rule or the inverse rule is used(More)
11:00 AM – 11:30 AM Generalized image charge solvation model for electrostatic interactions in molecular dynamics simulations of aqueous solutions (p. 70) 3:30 PM – 4:00 PM Dirichlet/Robin iteration-by-subdomain Schwarz-DDM for mul-tiphase fuel cell model with micro-porous layer (p. 60) 12:00 PM – 12:30 PM A Schwarz generalized eigen-oscillation spectral(More)
a r t i c l e i n f o a b s t r a c t A Wideband Fast Multipole Method (FMM) for the 2D Helmholtz equation is presented. It can evaluate the interactions between N particles governed by the fundamental solution of 2D complex Helmholtz equation in a fast manner for a wide range of complex wave number k, which was not easy with the original FMM due to the(More)
In this paper, we study electromagnetic wave scattering from periodic structures and eigenvalue analysis of the Helmholtz equation. Boundary element method (BEM) is an effective tool to deal with Helmholtz problems on bounded as well as unbounded domains. Recently , Oh et al.([29]) developed reproducing polynomial boundary particle methods (RPBPM) that can(More)
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