Min-Bin Chen

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BACKGROUND Numerous studies have yielded inconsistent results regarding the relationship between p53 status and the response to neoadjuvant radiation-based therapy in patients with rectal cancer. We conducted a meta-analysis to clarify the relationship between p53 status and response to radiation-based therapy in rectal cancer. METHODS/FINDINGS A total of(More)
The colorectal cancer is the leading contributor of cancer-related mortality. Mammalian target of rapamycin (mTOR), existing in 2 complexes (mTORC1/2), is frequently dysregulated and constitutively activated in colorectal cancers. It represents an important drug target. Here we found that INK-128, the novel ATP-competitive kinase inhibitor of mTOR, blocked(More)
  • Min-Bin Chen
  • 2011
Delaunay triangulation is a common mesh generation method in scientific computation. This parallel 3D Delaunay triangulation method uses domain-decomposition approach. With the properties of Delaunay triangulation, this method devise algorithm when merge block triangulations. To reduce the communications between processors, it finds the 3D affected zone(More)
Here we evaluated the anti-cancer activity of aqueous Oldenlandia diffusa (OD) extracts (ODE) in colorectal cancer (CRC) cells. We showed that ODE exerted potent anti-proliferative, cytotoxic and pro-apoptotic activities against a panel of established CRC lines (HCT-116, DLD-1, HT-29 and Lovo) and primary (patient-derived) human CRC cells. ODE activated(More)
SUMMARY This work describes a parallel divide-and-conquer Delaunay triangulation scheme. This algorithm finds the affected zone, which covers the triangulation and may be modified when two sub-block triangulations are merged. Finding the affected zone can reduce the amount of data required to be transmitted between processors. The time complexity of the(More)
BACKGROUND Numerous studies have yielded inconclusive results regarding the relationship between anti-apoptotic protein Bcl-2 expression and the sensitivity to chemotherapy in the patients with breast cancer. The purpose of the current study was therefore to elaborate their relationship. METHODS, FINDINGS A total of 23 previously published eligible(More)
Here we tested anti-tumor activity of KU-0060648 in preclinical hepatocellular carcinoma (HCC) models. Our results demonstrated that KU-0060648 was anti-proliferative and pro-apoptotic in established (HepG2, Huh-7 and KYN-2 lines) and primary human HCC cells, but was non-cytotoxic to non-cancerous HL-7702 hepatocytes. DNA-PKcs (DNA-activated protein kinase(More)
This paper reports on efficient parallel implementations of two-dimensional Delaunay triangulation in High Performance Fortran (HPF) and in Message Passing Interface (MPI). Our parallelization algorithm performs sub-block triangulation and boundary merge independently at the same time. The sub-block triangulation is by a divide & conquer Delaunay algorithm(More)
BACKGROUND Numerous studies have yielded inconclusive results regarding the relationship between tumor suppressor protein TP53 overexpression and/or TP53 gene mutations and the response to neoadjuvant chemotherapy in patients with breast cancer. The purpose of the current study was therefore to evaluate the relationship between TP53 status and response to(More)