Min-A Yoon

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Herpes virus entry mediator (HVEM) is a member of the TNF receptor (TNFR) superfamily and is expressed on many immune cells, including T and B cells, NK cells, monocytes, and neutrophils. Interaction of HVEM with its ligand, LIGHT, costimulates T cells and increases the bactericidal activity of monocytes and neutrophils. The interaction recruits cytoplasmic(More)
Herpes virus entry mediator (HVEM) is a member of the tumor necrosis factor receptor (TNFR) superfamily and is expressed on many immune cells. In this study we show that treatment of human monocytes with recombinant human LIGHT (rhLIGHT) induces rapid Ca<sup>2+</sup> influx in an HVEM-specific manner in parallel with the TNF-alpha production and enhances(More)
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