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OBJECTIVE In an effort to improve compliance with insulin therapy and to accelerate insulin pharmacokinetics, we tested the hypothesis that intradermal insulin delivery using a hollow microneedle causes less pain and leads to faster onset and offset of insulin pharmacokinetics in children and adolescents with type 1 diabetes (T1DM) compared with a(More)
We used the Immunochip array to analyze 2,816 individuals with juvenile idiopathic arthritis (JIA), comprising the most common subtypes (oligoarticular and rheumatoid factor-negative polyarticular JIA), and 13,056 controls. We confirmed association of 3 known JIA risk loci (the human leukocyte antigen (HLA) region, PTPN22 and PTPN2) and identified 14 loci(More)
Purpose Rheumatoid arthritis (RA) is an inflammatory arthritis with a peak onset age of ~50. Children with rheumatoid factor and/or anti-citrullinated peptide antibody positive juvenile idiopathic arthritis resemble adults with RA, and represent the childhood onset of RA (CORA). Variants of the genes encoding human leukocyte antigens (HLA) and several other(More)
Bacteria colonize cystic fibrosis (CF) airways, and although T cells with appropriate Ag specificity are present in draining lymph nodes, they are conspicuously absent from the lumen. To account for this absence, we hypothesized that polymorphonuclear neu-trophils (PMNs), recruited massively into the CF airway lumen and actively exocytosing primary(More)
BACKGROUND Although more than 100 non-HLA variants have been tested for associations with juvenile idiopathic arthritis (JIA) in candidate gene studies, only a few have been replicated. We sought to replicate reported associations of single nucleotide polymorphisms (SNPs) in the PTPN22, TNFA and MIF genes in a well-characterized cohort of children with JIA.(More)
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