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BACKGROUND The natural history, management, and outcome of takotsubo (stress) cardiomyopathy are incompletely understood. METHODS The International Takotsubo Registry, a consortium of 26 centers in Europe and the United States, was established to investigate clinical features, prognostic predictors, and outcome of takotsubo cardiomyopathy. Patients were(More)
AIMS Catheter-based renal nerve ablation (RNA) using radiofrequency energy is a novel treatment for drug-resistant essential hypertension. However, the local endothelial and vascular injury induced by RNA has not been characterized, although this importantly determines the long-term safety of the procedure. Optical coherence tomography (OCT) enables in vivo(More)
AIMS Takotsubo cardiomyopathy (TTC) remains a potentially life-threatening disease, which is clinically indistinguishable from acute myocardial infarction (MI). Today, no established biomarkers are available for the early diagnosis of TTC and differentiation from MI. MicroRNAs (miRNAs/miRs) emerge as promising sensitive and specific biomarkers for(More)
AIMS Regulatory T cells (Treg) exert anti-inflammatory and atheroprotective effects in experimental atherosclerosis. Treg can be induced against specific antigens using immunization strategies associated with clonal restriction. No data exist on Treg in combination with clonal restriction of T cells in patients with acute coronary syndromes (ACS). METHODS(More)
BACKGROUND Bioresorbable vascular scaffolds (BVS) have become an emerging tool to treat coronary artery disease. However, the current use of BVS is still widely restricted to stable patients and non-complex lesions. In real-world practice patients are far more complex than those with simple type A lesions and the extended use of BVS to complex lesions and(More)
An 82-year-old female after a stress event, with no past medical history of cardiovascular diseases , was referred for emergency coronary angiography. She was suffering from chest pain, with a blood pressure of 124/67 mmHg and a heart rate of 76 b.p.m. Prominent ST-segment elevation in V1–V5 and increased troponin I level (14.82 ng/mL) suggested(More)
Acute coronary syndromes are frequently caused by " vulnerable " coronary plaques with a lipid-rich core. In 1993 near-infrared spectroscopy (NIRS) was first used to detect the lipid (cholesterol) content of atherosclerotic plaques in an experimental animal study. NIRS was then carefully validated using human atherosclerotic plaques (ex vivo), and has(More)
events associated with testosterone administration. dysfunction in heart failure: correlation with severity, exercise performance, co-morbidities, and heart failure treatment. Krumholz HM. Patterns and loss of sexual activity in the year following hospitalization for acute myocardial infarction (a United States National Multisite Observational Study). An(More)
PURPOSE Beyond antiproliferative properties, paclitaxel exhibits anti-inflammatory activity, which might be beneficial in the local treatment of nonocclusive coronary artery disease. Paclitaxel release and tissue concentrations after paclitaxel-coated balloon treatment using different pressures have not been investigated so far. The aim of the study was to(More)
The pianist Carl Czerny, a pupil of Beethoven, reports in his book On the Proper Performance of all Beethoven's Works for the Piano an interesting anecdote. The young Anton Halm presented the master a sonata that he had just composed. Beethoven looked through it without finding anything that aroused his attention and after a few minutes gave the young(More)