Milosz Jaguszewski

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AIMS Takotsubo cardiomyopathy (TTC) remains a potentially life-threatening disease, which is clinically indistinguishable from acute myocardial infarction (MI). Today, no established biomarkers are available for the early diagnosis of TTC and differentiation from MI. MicroRNAs (miRNAs/miRs) emerge as promising sensitive and specific biomarkers for(More)
AIMS Catheter-based renal nerve ablation (RNA) using radiofrequency energy is a novel treatment for drug-resistant essential hypertension. However, the local endothelial and vascular injury induced by RNA has not been characterized, although this importantly determines the long-term safety of the procedure. Optical coherence tomography (OCT) enables in vivo(More)
AIMS Regulatory T cells (Treg) exert anti-inflammatory and atheroprotective effects in experimental atherosclerosis. Treg can be induced against specific antigens using immunization strategies associated with clonal restriction. No data exist on Treg in combination with clonal restriction of T cells in patients with acute coronary syndromes (ACS). METHODS(More)
Acute coronary syndromes are frequently caused by " vulnerable " coronary plaques with a lipid-rich core. In 1993 near-infrared spectroscopy (NIRS) was first used to detect the lipid (cholesterol) content of atherosclerotic plaques in an experimental animal study. NIRS was then carefully validated using human atherosclerotic plaques (ex vivo), and has(More)
BACKGROUND Bioresorbable vascular scaffolds (BVS) have become an emerging tool to treat coronary artery disease. However, the current use of BVS is still widely restricted to stable patients and non-complex lesions. In real-world practice patients are far more complex than those with simple type A lesions and the extended use of BVS to complex lesions and(More)
PURPOSE Beyond antiproliferative properties, paclitaxel exhibits anti-inflammatory activity, which might be beneficial in the local treatment of nonocclusive coronary artery disease. Paclitaxel release and tissue concentrations after paclitaxel-coated balloon treatment using different pressures have not been investigated so far. The aim of the study was to(More)
A 74-year-old man presented with ST elevation myo-cardial infarction (STEMI) on the 15 th day of antibiotic therapy due to aortic valve staphylococcal endocardi-tis. The coronary angiography revealed occlusion of the left anterior descending artery (LAD) (Figure 1 A). Initial aspiration thrombectomy (AT) with an Export AP (Medtronic Vascular) catheter(More)
The pianist Carl Czerny, a pupil of Beethoven, reports in his book On the Proper Performance of all Beethoven's Works for the Piano an interesting anecdote. The young Anton Halm presented the master a sonata that he had just composed. Beethoven looked through it without finding anything that aroused his attention and after a few minutes gave the young(More)
BACKGROUND ECG criteria differentiating Takotsubo cardiomyopathy (TTC) from mainly anterior myocardial infarction (MI) have been suggested; however, this was in small patient populations. METHODS AND RESULTS Twelve-lead admission ECGs of consecutive 200 TTC and 200 MI patients were compared in dichotomized groups based on the presence or absence of(More)
Optical coherence tomography (OCT) is a high-resolution imaging technique that is increasingly used for intracoronary imaging to characterize coronary atherosclerotic plaques and vascular responses after coronary stent implanta-tion. Introduction of optical frequency-domain imaging (OFDI; second generation OCT) has simplified practical use of this novel(More)
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