Milijanka Krstić

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Cyproheptadine and R 50 656, a novel 5-HT2 antagonist, produced a dose-dependent suppression of the pressor response to 5-hydroxytryptamine (5-HT), but did not affect the depressor response. The pressor effect of 5-HT was significantly more sensitive to R 50 656 than to cyproheptadine. On the contrary, the tachycardic response to 5-HT was antagonized only(More)
Vasopressin causes endothelium-independent contractions of the rat arteries being a potent full agonist in the aorta and renal artery, but a weak partial agonist in the common carotid artery. The contractile effect in the aorta and renal artery was observed with concentrations similar to those detected in circulating blood during hemorrhage, septic shock,(More)
General characteristics and the nature of cardiovascular responses to acetylcholine (ACh) injected into the lateral cerebral ventricle (LCV), the 4th cerebral ventricle (4th CV) and the cisterna magna (CM) were studied. Acetylcholine, depending on the route of injection, the dose and the peripheral vascular tone, produced both increases and decreases in(More)
The response of the isolated renal artery to histamine was analysed. The renal artery in relaxed state did not respond to histamine. However, in the precontracted renal artery with phenylephrine, histamine (10(-8)-10(-4) mol/l) caused a concentration-dependent relaxation. Removal of the vascular endothelium abolished the relaxant response to smaller(More)
The effect of histamine on the isolated rat common carotid, renal and cranial mesenteric arteries was examined. Histamine (10(-8)-10(-4) M) caused concentration-dependent relaxations of the arteries during contractions induced with phenylephrine (10(-8)-10(-7) M). Removal of the vascular endothelium inhibited the histamine-induced relaxations. Pyrilamine (6(More)
5-Hydroxytryptamine (5-HT) administered intraventricularly (i.vent.) in rats produced hypertension without considerable changes in heart rate. After transsection of the spinal cord or i.vent. administration of methysergide, 5-HT failed to produce the pressor effect. Thus, the hypertension results from the activation of 5-HT receptor sites of the rat brain.