Milica Popovich

  • Citations Per Year
Learn More
Hyperthyroid rat heart was studied with the purpose of identifying the mechanism for the significant decrease in total creatine (free creatine plus phosphocreatine) observed in this pathology and its consequences on heart function. Administration of L-thyroxine in doses of 50-100 micrograms/100 g of body weight during a week resulted in a reversible(More)
Changes in high-energy phosphate content and cardiac contractile function of isolated rat hearts as well as changes in Ca2+ sensitivity and mitochondrial respiration of myocardial skinned fibers were assessed in hereditary cardiomyopathies and in cardiomyopathies induced by chronic treatment with adriamycin or norepinephrine, by autoimmunization, by(More)
The high-energy-phosphate content, myocardial ultrastructure, left ventricular (LV) pressure, and pump function of isolated rat hearts were determined in four kinds of chronic myocardial damage induced by either autoimmunization, treatment of rats with adriamycin or noradrenaline in increasing doses, or infection with smallpox virus. Mild fibrosis, swollen(More)
A steadily increasing dose of norepinephrine given to rats for 7 consecutive days (cumulative dose 25 mg/kg) resulted in the development of focal necrotic areas with abundant collagen fibers, marked hypertrophy of cardiomyocytes and a mild depletion of the myocardial level of high-energy phosphates. These changes were associated with a more than two-fold(More)
Left ventricular (LV) contractile function and pump function were depressed in isolated working hearts from rats treated with either guanidinopropionic acid (GPA), an inhibitor of creatine influx, or the anthracycline antibiotic, adriamycin, for 6 and 10 weeks, respectively. In both groups of treated animals myocardial phosphocreatine content was lower than(More)
Prolonged noradrenaline administration to rats in steadily increasing dosages for a period of one to four weeks (cumulative doses 25-35 mg/kg) resulted in the development of focal necrotic areas with abundant collagen fibers and marked hypertrophy of cardiomyocytes. Cellular diameter was higher by 37-44% and extracellular space area by 70-100%. A(More)
Alterations in the heart energy metabolism, early defects in cardiomyocyte sarcolemma and heart resistance to ischemic damage have been investigated in experimental autoimmune cardiomyopathy. Systolic and diastolic pressures were registered and the speed of ischemic contracture development was determined on the isolated perfused rat hearts. Oxidative(More)
An increase in the diastolic rigidity of the myocardium is a common pathogenetic feature of many diseases of the human heart, including in various types of cardiomyopathy [4, 5, I0]. One of these, frequently combined with congestive heart failure, is the cardiomyopathy arising during long-term treatment of neoplastic diseases with adriamycin. The cause of(More)
4-week administration of adriamycin (20 mg/kg) to rats resulted in the death of approximately one third of the animals, the minute volume of isolated hearts of the surviving animals was less than half of the normal value and the level of phosphocreatine was decreased by one third. The hearts of the rats receiving the same dose of the drug over 10 weeks(More)