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Much progress has been made in understanding the complex pharmacokinetics of trichloroethylene (TCE) . Qualitatively, it is clear that TCE is metabolized to multiple metabolites either locally or into systemic circulation. Many of these metabolites are thought to have toxicologic importance. In addition, efforts to develop physiologically based(More)
Carbofuran (2, 3-dihydro-2, 2-dimethyl-7-benzofuranyl-N-methylcarbamate), a broad spectrum N-methyl carbamate insecticide, and its metabolite, 3-hydroxycarbofuran, exert their toxicity by reversibly inhibiting acetylcholinesterase (AChE). To characterize AChE inhibition from carbofuran exposure, a physiologically-based pharmacokinetic/pharmacodynamic(More)
Attached, please find the meeting minutes of the FIFRA Scientific Advisory Panel open meeting held in Arlington, Virginia on February 15-18, 2005. This report addresses a set of scientific issues being considered by the Environmental Protection Agency pertaining to the N-methyl carbamate cumulative risk assessment: pilot cumulative analysis. NOTICE These(More)
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