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Beat detection algorithms have many clinical applications including pulse oximetry, cardiac arrhythmia detection, and cardiac output monitoring. Most of these algorithms have been developed by medical device companies and are proprietary. Thus, researchers who wish to investigate pulse contour analysis must rely on manual annotations or develop their own(More)
We designed a new methodology to estimate the pulse pressure variation index (deltaPP) in arterial blood pressure (ABP). The method uses automatic detection algorithms, kernel smoothing, and rank-order filters to continuously estimate deltaPP. The technique can be used to estimate deltaPP from ABP alone, eliminating the need for simultaneously acquiring(More)
OBJECTIVE To describe a real-time, continuous physiologic data acquisition system for the study of disease dynamics in the intensive care unit. DESIGN Descriptive report. SETTING A 16-bed pediatric intensive care unit in a tertiary care children's hospital. PATIENTS A total of 170 critically ill or injured pediatric patients. INTERVENTIONS None. (More)
Healthy physiological systems exhibit marked signal variability and complexity, whereas diseased systems generally show a loss of variability, decreased complexity ("decomplexification"), and increased regularity. The goal of this study was to evaluate the uncoupling and recoupling phenomenon in children with septic shock by observing serial changes in(More)
Intracranial pressure (ICP) monitoring and management have substantially improved the outcome of patients with traumatic brain injury (TBI). However, rapid elevations in ICP remain a significant problem as they may lead to secondary brain injury and worse outcome due to cerebral is-chemia. Current therapy is targeted towards treating rapid ICP elevations(More)
OBJECTIVE To describe and report the reliability of a portable, laptop-based, real-time, continuous physiologic data acquisition system (PDAS) that allows for synchronous recording of physiologic data, clinical events, and event markers at the bedside for physiologic research studies in the intensive care unit. DESIGN Descriptive report of new research(More)
This brief review is aimed primarily as a resource for the clinician and summarizes recent advancements in electrocardiographic monitoring in the intensive care unit. Emphasis is placed on recent advances in ICU ECG and cardiac event monitoring with particular attention to arrhythmia detection in patients following myocardial infarction. Specific topics(More)
Sepsis is a systemic reaction to an infection that can lead to septic shock, organ dysfunction and, eventually, death. If septic shock or episodes of hypotension could be predicted, preventative measures might reduce organ damage and prevent death. In this paper we describe statistically sensitive time-domain changes in the arterial blood pressure (ABP)(More)
— We describe a new resource for developers of QRS detection algorithms that provides a standardized assessment of algorithm performance that is blinded, objective, independent, and reproducible. This overcomes the problems of using a single data set for both development and assessment that leads to favorably biased estimates of performance.
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