Miles J. Dixon

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Class I phosphoinositide (PI) 3-kinases act through effector proteins whose 3-PI selectivity is mediated by a limited repertoire of structurally defined, lipid recognition domains. We describe here the lipid preferences and crystal structure of a new class of PI binding modules exemplified by select IQGAPs (IQ motif containing GTPase-activating proteins)(More)
Background: Phosphoinositide 3-kinase lipid signals exert important biological effects through proteins with specific recognition domains. Results: We identify a novel such protein domain in IQGAP proteins and define its crystal structure and phosphoinositide binding preferences. Conclusion: This domain is a distinct cellular phosphatidylinositol(More)
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