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BACKGROUND Optimal vascular function is vital for prevention of dementia. We hypothesized that elderly post-stroke survivors who preserve cognitive function show unperturbed cerebral microvasculature compared with those who develop dementia. METHODS Using stereological spherical probe software, we compared the length density (Lv, cumulative vessel length(More)
We studied 97 children and adolescents with essential hypertension by evaluating photographs of the optic fundus and fluorescein angiography. Photographs were examined for the presence of arteriolar narrowing, tortuosity, and arteriovenous nicking. Intraobserver and interobserver variability in determination of abnormalities was low with agreement of 75%(More)
The suitability of tetrodotoxin (TTX) for studies of the neural control of vascular smooth muscle (VSM) tone in the microcirculation was evaluated by determining 1) whether TTX blockade of neural input to adrenergically innervated VSM is reversible and 2) whether TTX depresses active VSM tone directly. Diameters of rat mesenteric veins and third- and(More)
To determine whether genetic markers for chronic iridocyclitis could be identified, we used both serologic and oligonucleotide dot blot techniques to characterize immunogenetically 164 children with early-onset pauciarticular juvenile rheumatoid arthritis. Seventy-eight children (47.6%) had chronic iridocyclitis and 86 (52.4%) had not had evidence of eye(More)
BACKGROUND Magnetic resonance imaging indicates diffuse white matter (WM) changes are associated with cognitive impairment in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). We examined whether the distribution of axonal abnormalities is related to microvascular pathology in the underlying WM. METHODS(More)
BACKGROUND & AIMS We report a novel approach to study biliary water, bile acid, and HCO(3)(-) transport: the microperfusion of intrahepatic bile duct units (IBDUs) isolated from normal rat liver. METHODS To study water transport, IBDUs were perfused in vitro with a membrane-impermeant fluorescent volume marker, fluorescein sulfonate; net water movement(More)
Factors potentially associated with the formation or prevention of coronary artery aneurysms were investigated in 77 children with Kawasaki disease. The patients were divided into two groups. Group A consisted of those who developed coronary artery aneurysms and group B consisted of those who did not. The patients who developed aneurysms had a significantly(More)
The risk of iridocyclitis in children with early onset pauciarticular juvenile rheumatoid arthritis (EOPA-JRA) has been shown to be associated with certain HLA haplotypes. Our report contains an actuarial analysis, using one-year intervals, of 161 subjects and estimates haplotype specific risks. Individuals who possess the major susceptibility haplotype(More)
Information is reviewed on the ophthalmologic findings in 614 individuals with Rubinstein-Taybi syndrome (RTS). The data were collected from the world literature, from communication with colleagues and with families of individuals with RTS, and from personal observations. Particular emphasis is given in this article to the association of RTS with glaucoma(More)