Milene Moehlecke

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Body weight is regulated by the ability of hypothalamic neurons to orchestrate behavioral, endocrine and autonomic responses via afferent and efferent pathways to the brainstem and the periphery. Weight maintenance requires a balance between energy intake and energy expenditure. Although several components that participate in energy homeostasis have been(More)
AIM To determine whether systolic and diastolic blood pressure (BP) means, during ambulatory BP monitoring (ABPM), are more strongly correlated with microvascular complications and echocardiographic structural alterations than night-time/daytime (N/D) BP ratio. METHODS A cross-sectional study was conducted in 270 Type 2 diabetes mellitus (DM) outpatients(More)
BACKGROUND The ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) gene is a candidate gene for insulin resistance. Insulin resistance is a major component of metabolic syndrome (MetS) and has been implicated in ischemic heart disease (IHD). OBJECTIVE To evaluate the association between the K121Q polymorphism of the ENPP1 gene and IHD in white(More)
The objective of this study was to evaluate the effect of metabolic syndrome (MetS) and its individual components on the renal function of patients with type 2 diabetes mellitus (DM). A cross-sectional study was performed in 842 type 2 DM patients. A clinical and laboratory evaluation, including estimated glomerular filtration rate (eGFR) calculated by the(More)
Imbalances in the gut microbiota, the bacteria that inhabit the intestines, are central to the pathogenesis of obesity. This systematic review assesses the association between the gut microbiota and weight loss in overweight/obese adults and its potential manipulation as a target for treating obesity. This review identified 43 studies using the keywords(More)
Obesity during pregnancy and excessive weight gain during this period are associated with several maternal-fetal and neonatal complications. Moreover, a significant percentage of women have weight retention in the postpartum period, especially those with excessive weight gain during pregnancy. The recommendations of the 2009 Institute of Medicine were based(More)
Background Weight gain may be associated with an imbalance between energy intake and energy expenditure. The resting metabolic rate (RMR) is the main component of total energy expenditure, and is related mainly to lean mass (LM), as well as to other factors such as fat mass (FM), age, sex and genetic factors. A RMR lower than expected may be a risk factor(More)
Background Weight loss usually decreases energy expenditure (EE) because of changes in body composition (BC). The reduction in EE may contribute, in part, to long-term weight regain. Patients undergoing bariatric surgery might experience a decrease in EE, mainly due to reduced resting metabolic rate (RMR), explained by a decreased lean body mass (LBM),(More)
BACKGROUND Weight loss and body composition changes after Roux-en-Y gastric bypass (RYGB) may influence resting energy expenditure (REE). The effect of lower REE after the procedure on long-term weight remains to be elucidated. OBJECTIVE To evaluate the effects of RYGB on REE and body composition 6 months after RYGB and to find out whether postsurgery REE(More)
Background Obesity is associated with a state of low-grade chronic inflammation, commonly causing insulin resistance (IR) and type 2 diabetes mellitus (T2D). The NLRP3 inflamassome is a key mediator of metabolic inflammation, and it has been shown to be activated in macrophages of newly diagnosed insulin resistant-T2D patients. In humans, reduction in NLRP3(More)