Milena de Barros Viana

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There has been an increasing interest in the development of animal models that address different types of anxiety disorders. The elevated T-maze (ETM) was developed based on the assumption that inhibitory avoidance and one-way escape are respectively related to generalized anxiety (GAD) and panic disorder (PD). Although anxiolytic effects on the inhibitory(More)
Analysis of Fos protein expression was used to map brain areas activated by exposure of male Wistar rats to the elevated T-maze, an animal model of anxiety where tasks of inhibitory avoidance or one-way escape can be separately performed. The apparatus consists of three elevated arms--one enclosed and two open. In the inhibitory avoidance task--considered(More)
Genotoxicity is the ability of an agent to produce damage on the DNA molecule. Considering the strong evidence for a relationship between genetic damage and carcinogenesis, to elucidate the putative mechanisms of genotoxicity induced by fluoride are important to measure the degree of risk involved to human populations. The purpose of this article is to(More)
Genotoxicity is the capacity of an agent to produce damage in the DNA molecule. Considering the strong evidence for a relationship between genetic damage and carcinogenesis, evaluation of genotoxicity induced by dental materials is necessary for elucidating the true health risks to patients and professionals. The purpose of this article was to provide a(More)
Drug addiction is a chronically relapsing disorder characterized by compulsion to seek and take the drug, loss of control in limiting intake and, eventually, the emergence of a negative emotional state when access to the drug is prevented. Both dopamine and corticotropin-releasing factor (CRF)-mediated systems seem to play important roles in the modulation(More)
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