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Applications of tandem mass spectrometry (MS/MS) techniques coupled with high-performance liquid chromatography (HPLC) in the identification and determination of phase I and phase II drug metabolites are reviewed with an emphasis on recent papers published predominantly within the last 6 years (2002-2007) reporting the employment of atmospheric pressure(More)
Rhodamine 123 (Rho123), a model substrate of P-glycoprotein (P-gp), was used to evaluate the functional activity of P-gp efflux transporter in the rat placental barrier. The dually perfused rat-term placenta method was used. In our experiments, the materno-fetal transplacental passage of Rho123 did not meet the criteria of the first-order pharmacokinetics,(More)
The aim of present project was to find out if in vivo contact of Haemonchus contortus with benzimidazole an-thelmintic flubendazole (FLU) during treatment of its hosts (sheep) with low doses of FLU affects helminths' drug-metabolizing enzyme activities. Four groups of lambs, experimentally infected with H. contortus, were treated three-times orally with(More)
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