Milan Javůrek

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A functional structure-classification of programs for analysis of spectra elucidates their efficiency for determination of the stoichiometric indices, stability constants and molar absorptivities of complex species. SQUAD (84) introduces new functional units for (i) determination of the number of light-absorbing species, (ii) a rigorous fitness test, (iii)(More)
The resolving power of multicomponent spectral analysis and the computation reliability of the stability constants and molar absorptivities determined for five variously protonated anions of physostigmine salicylate by the SQUAD(84) and SPECFIT/32 programs has been examined with the use of simulated and experimental spectra containing overlapping spectral(More)
MRFIT and MRLET, two FORTRAN computer programs, can analyse a photometric mole-ratio curve (photometric titration curve) to estimate the stability constant beta(pq) of the predominant complex M(p)L(q), the ligand concentration factor f(L), the extrapolated absorbance A(ext) and the stoichiometric coefficient q (p is usually 1). MRFIT uses algorithmic(More)
The resolving power of multicomponent spectra analysis and the computation reliability of the stability constants and molar absorptivities determined for nine variously protonated anions of three sulphonephthaleins and an impurity, by analysis of data for a mixture by programs SQUAD(84) and PSEQUAD(83), has been examined by use of synthetic and(More)
Our field experiments showed that the use of Czech biopreparations (Supresivit, Ibefungin and Polyversum) based on the following microorganisms: Trichoderma harzianum, Bacillus subtilts and Pythium oligandrum applied as the seed treatment, the spray on the plants and like the mixture with mineral fertilizers (NPK, ammonium sulphate) lead namely after the(More)
Potentiometric and spectrophotometric pH-titration of the multiprotic cytostatics bosutinib for dissociation constants determination were compared. Bosutinib treats patients with positive chronic myeloid leukemia. Bosutinib exhibits four protonatable sites in a pH range from 2 to 11, where two pK are well separated (ΔpK>3), while the other two are near(More)
The program SPOPT estimates stability constants beta(pqr) and molar absorptivities epsilon(pqr) of all light-absorbing species M(p)L(q)H(r) by analysis of the absorbance-concentration (or absorbance-pH) curve. The program DCMINUIT estimates dissociation constants and molar absorptivities of protonated species. Both programs have been tested and compared(More)
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