Milan Draganov

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The cytotoxicity of test agents on serum-free McCoy cultures has not been studied at all. The cytotoxic effect of EDTA, methanol, DMSO, and cycloheximide on serum-free McCoy-Plovdiv cell culture (SF) was detected visually on inverted microscope and quantitatively by tests for viability (NR) and total protein (KBP). The IC50 values for the tested chemicals(More)
The mesencephalic trigeminal nucleus (MTN) is a unique structure in the central nervous system (CNS). It is composed of primary sensory neurons, which are mainly typical of dorsal root ganglia. The afferent projections of the MTN neurons are relatively well studied, although the data about the efferents are still controversial. The goal of the present study(More)
McCoy-Plovdiv cells represent a serum-free in vitro system, which is suitable not only for diagnostic purposes but also for studies on the biological activity of different substances. In addition, it can be used for developing an expression system for production and purification of various proteins. Isolation of successfully transfected cells is an(More)
Investigations were carried out on the outbreak and spread of foot rot in sheep as well as on the ways of its restriction and eradication. It was found that the disease had been introduced with the import of breeding animals, its further spread being associated with the activity of the Breeding Centers for pedigree animals. The diseased animals have been 25(More)
Bacterial infection often causes clinical complications and failure of indwelling medical devices. This is a major problem of current ureteral stents, which are used clinically to treat the blockage of ureteral canals. This study investigates the effectiveness and applicability of magnesium as a novel biodegradable ureteral stent material that has inherent(More)
In normal circumstances, galanin (GAL) and neuropeptide Y (NPY), a peptide usually occurring in sympathetic neurons, are not found in the neurons of the mesencephalic trigeminal nucleus (MTN), a unique locale of (pseudo)unipolar sensory neurons in the central nervous system. Nonetheless, both peptides have been shown to be up-regulated in primary afferent(More)
A live vaccine was produced against the salmonellosis abortion in sheep with the use of an attenuated (chemically) strain of Salmonella abortus ovis. It was tested comparatively with a killed vaccine in sheep under experimental conditions. The dynamics of the agglutinating antibodies was followed up after immunization with the two vaccines, studying also(More)