Mikuláš Pomfy

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The freely diffusible radical, nitric oxide (NO), has been assumed to act as a retrograde signaling molecule that modulates transmitter release. Acetylcholine (ACh) is known to function as a typical neurotransmitter. In the present work we have examined the presence of both transmitters (NO and ACh) and their possible relations in the rabbit spinal cord. In(More)
Ischaemic/reperfusion (IR) injury of the small intestine may lead to the development of multiple organ failure. Little is known about the morphological changes occurring in the organs during the subacute course of this syndrome. The objective of this study was to observe histopathological features and the role of apoptosis in the jejunal mucosa and lung(More)
The state of cerebral ischemia and the following recirculation affect also the blood rheology. The erythrocyte microrheology was studied less than the blood plasma changes. The presented paper is focused on the erythrocyte microrheology changes after global brain ischemia. Both mild and serious global ischemia were induced by the exclusion of cerebral blood(More)
New facts about control of nuclear milieu were recently described. Because calcium is known as an important cellular regulator we designed this study to describe temporal calcium kinetics in neuronal nuclei in canine neocortex after ischemia-reperfusion injury. Seven-minute global cerebral ischemia was followed by reperfusion phase lasting from 0 to 24(More)
Decreasing ischemia-reperfusion injury in intestinal transplantation is of paramount importance for improving graft recovery and function. This study explores the ability of two ischemic preconditioning (IPC) regimens to reduce preservation injury. Sprague-Dawley rats were divided into 3 groups (n = 11 each). In the controls (group C), intestinal grafts(More)
The study was focused on the changes in morphological structure of cerebral microcirculation after two stages of 7 min dog's total brain ischaemia followed by 24 recirculation. In the first experimental group (brain blood pressure 2.5-3.0 kPa), there was observed ultrastructural picture of damaged microvessels, including dilated and irregularly shaped(More)
BACKGROUND Intestinal transplantation (ITx) represents difficult life-saving intervention reserved for patients with irreversible intestinal failure. A serious complication of ITx is jejunal graft (JG) damage. The aim of the study was to evaluate the development of JG damage during ITx and determine the share of pathological elements (mechanical(More)
Of the serotonin occurring in the small bowel mucosa, 95% is present in enterochromaffine cells. The cold ischemia during small bowel transplantation results in mucosal injury and releasing of serotonin into the lumen. Because of it, the mucosal concentration of serotonin is decreasing. The aim of our study was to establish the correlation between changes(More)
Vascular diseases of the CNS are a major medical, social and economic problem. From the number of causes leading to nervous malfunction and damage, ischemia is most prominent. Thus, neuronal protection from ischemic damage may provide significant preventive and treatment potential. This study was designed to test possible protective effects of stobadine in(More)
A new model of transient global cerebral ischemia in dogs with minimal measures of intervention is described together with a simple scale for evaluation of functional outcome. During pentobarbital anesthesia, a global cerebral ischemia lasting seven minutes was induced by a four-vessel occlusion and a controlled systemic hypotension. The reperfusion phase(More)