Mikolaj Donten

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The interaction between silver nanoparticles and herpesviruses is attracting great interest due to their antiviral activity and possibility to use as microbicides for oral and anogenital herpes. In this work, we demonstrate that tannic acid modified silver nanoparticles sized 13 nm, 33 nm and 46 nm are capable of reducing HSV-2 infectivity both in vitro and(More)
To limit cytotoxicity of anticancer drugs against healthy cells, an appropriate carrier should be synthesized to deliver the drug to the tumor tissue only. A good solution is to anchor a magnetic nanoparticle to the molecule of the drug and to use a properly directed external magnetic field. The synthesis of the conjugate of doxorubicin with magnetic(More)
A method is presented for the electroanalytical characterization of interactions of dsDNA with a drug, under conditions that both agents are dissolved in the phosphate buffer solution and both are electroactive. Normal pulse, square wave, differential pulse, and cyclic voltammetries were employed in the measurements of the drug and dsDNA oxidation signals(More)
Magnetic drug targeting executed by nanoparticles as carriers is a promising cancer treatment which avoids the side effects of conventional chemotherapy. We have modified doxorubicin with magnetic nanoparticles. Doxorubicin (adriamycin) is a potential anticancer drug yet nonspecific in its antibiotic action. Therefore, carriers for tissue-specific, targeted(More)
Formation of thin layers of the composite material by a method based on interphase polymerization induced by a transport-controlled redox reaction is described. The obtained films were of 0.2-1 microm thickness, consisted of polypyrrole and gold nanoparticles (up to 13.5 at. %), strongly adhered to the substrate surface, and were uniform. Different carbon(More)
Composites consisting of ss- and ds-DNA strands and polyacrylamide (PAM) hydrogel have been synthesized. DNA was entrapped non-covalently. The obtained DNA biomaterial exhibited a strong increase in guanine and adenine anodic currents when temperature reached the physiological level. This increase was related to the unique oligonucleotide structural changes(More)
An effective, fast, facile and direct electrochemical method of determination of hemoglobin (Hb) in blood sample without any sample preparation is described. The method is accomplished by using the ferromagnetic electrode modifier (carbon-encapsulated iron nanoparticles) and an external magnetic field. The successful voltammetric determination of hemoglobin(More)
The influence of stream orientation versus surface of microelectrode detector was examined in the range between vertical and parallel flow for various jet velocities and various levels of supporting electrolyte. The flow cell was equipped with a conical body Pt microdisk electrode, and the measurements involved voltammetry and chronoamperometry. Ferrocene,(More)
Poly(N-vinylcarbazole) films can be deposited at the three-phase boundary when the organic phase contains only monomer, N-vinylcarbazole, while the aqueous phase contains supporting electrolyte. A cylindrical platinum microelectrode is immersed into the two-liquid system in such a way that a part of it is located in one liquid and the other part resides in(More)
The electrooxidation of double-stranded DNA (dsDNA) from calf thymus was carried by using cyclic voltammetry. A glassy carbon disk-, a platinum disk-, a platinum mesh- and a carbon vapor-deposited platinum mesh electrodes were used. It is shown that the appropriate chemical and biological (steam treatment) purification of the complete cell allows, for the(More)