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The activation peptide of mammalian trypsinogens contains a highly conserved tetra-aspartate sequence (D19-D20-D21-D22) preceding the K23-I24 scissile peptide bond, which is hydrolyzed as the first step in the activation process. Here, we examined the evolution and function of trypsinogen activation peptides through integrating functional characterization(More)
The orphan receptor APJ and its recently identified endogenous ligand, apelin, exhibit high levels of mRNA expression in the heart. However, the functional importance of apelin in the cardiovascular system is not known. In isolated perfused rat hearts, infusion of apelin (0.01 to 10 nmol/L) induced a dose-dependent positive inotropic effect (EC50:(More)
The study of pheromones of click beetles was started with the objective of applying similar methods in IPM strategies for the control of wireworms, based on the similar experience gained from the widely used moth pheromones. A brief overview is presented on the identification of click beetle pheromones, new questions arising in the categorization of these(More)
OBJECTIVE In diabetes mellitus several cardiac electrophysiological parameters are known to be affected. In rodent experimental diabetes models changes in these parameters were reported, but no such data are available in other mammalian species including the dog. The present study was designed to analyse the effects of experimental type 1 diabetes on(More)
The superfamily Scarabaeoidea comprises a large and diverse monophyletic group. Members share ancestral characteristics, but often exhibit considerable differences in their ecology, physiology, or mating strategies. A large number of species are regarded as pests of crop or amenity plants, while others are beneficial to humans and even may be extremely rare(More)
BACKGROUND Adrenomedullin (ADM), a new vasorelaxing and natriuretic peptide, may function as an endogenous regulator of cardiac function, because ADM and its binding sites have been found in the heart. We characterize herein the cardiac effects of ADM as well as the underlying signaling pathways in vitro. METHODS AND RESULTS In isolated perfused, paced(More)
OBJECTIVE This study sets out to demonstrate the normal developmental steps of the tegmen tympani and thus explains the typical localization of congenital tegmental defects. SPECIMENS For this study, 79 macerated and formalin-fixed human temporal bones from 14th fetal week to adults were observed and prepared. INTERVENTION Macroscopic and microscopic(More)
UNLABELLED The High Resolution Research Tomograph (HRRT) is the PET system providing the highest resolution for imaging of the human brain. In this study, the improved quantitative performance of the HRRT was evaluated in comparison with a previously developed lower resolution PET system, the ECAT HR. The radioligand [(11)C]MADAM was chosen for the purpose(More)
BACKGROUNDS AND PURPOSE The main objectives of the present study were (i) to measure density changes of activated microglia and the peripheral benzodiazepine receptor/translocator protein (TSPO) system during normal ageing in the human brain with positron emission tomography (PET) using the TSPO molecular imaging biomarker [(11)C]vinpocetine and (ii) to(More)
Field experiments were carried out to ascertain whether synthetic floral odour compounds were attractive for two pest bug species. The European tarnished plant bug (Lygus rugulipennis Poppius) has been reported to damage various crops (e.g. strawberry, sugarbeet, alfalfa, cucumber), and the alfalfa plant bug (Adelphocoris lineolatus (Goeze)) is considered(More)