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BACKGROUND Manganese, an essential micronutrient, is a potential neurotoxicant in prolonged overexposure. Parkinson-like syndrome, motor deficit, disturbed psychomotor development are typical signs of neuropathological alterations due to Mn in humans. METHODS Young adult rats, in three groups of 16 each, received 15 and 59 mg/kg b.w. MnCl(2), (control:(More)
The effects of cobalt sulfate administered to pregnant C57BI mice, OFA-SD rats, and New Zealand rabbits was studied on fetal and postnatal offspring. Cobalt concentration in the maternal blood was increased in proportion to the administered doses. Cobalt crossed the placenta and appeared in the fetal blood and amniotic fluid. Regardless of the administered(More)
Lead content of ovarian follicular fluid obtained from 23 women was determined by atomic absorption spectrophotometry. In an in vitro experiment the direct effect of lead on the morphology and on progesterone (P) production by cultured granulosa cells of six women was investigated. Follicular fluid and granulosa cells were obtained from follicular aspirates(More)
OBJECTIVE Report of a lead intoxication epidemic caused by ingestion of contaminated ground paprika. DESIGN Retrospective study of case histories. SETTING Institutional, toxicological and medical referral center for ambulatory and hospitalized care. PATIENTS One hundred forty-one adults consumed paprika contaminated with lead tetroxide (red lead). (More)
In order to investigate the genotoxic effects of occupational acrylonitrile (ACN) and dimethylformamide (DMF) exposures, clinical serum and urine parameters and genotoxicological endpoints such as chromosome aberration (CA), sister chromatid exchange (SCE), high frequency SCE (HFC), cell cycle kinetics, and UV-induced unscheduled DNA synthesis (UDS) were(More)
OBJECTIVE Phthalates and their metabolites are classified as endocrine modulators. They affect the hormonal balance in both children and adults. The aim of this publication was to compare the urinary levels of phthalate metabolites in selected populations of the Czech Republic (CZ), Slovakia (SK), and Hungary (HU) in relation to the sources of phthalate(More)
In male Wistar rats, behavioral and electrophysiological investigations, and blood and brain manganese level determinations, were performed; during 10 weeks treatment with low-dose manganese chloride and a 12 weeks post-treatment period. Three groups of 16 animals each received daily doses of 14.84 and 59.36mg/kg b.w. MnCl(2) (control: distilled water) via(More)
Young adult male Wistar rats (24/group) were treated for 5 weeks with methyl mercury(II)chloride (corresponding to 0.5 and 2.0mgHg°/kg b.w., control: distilled water) by gavage, followed by a 19 weeks post-treatment period. Spontaneous motility, psychomotor performance and sensorimotor gating was repeatedly tested, electrophysiological recordings done, in(More)
The respiratory bio-accessibility of a substance is the fraction that is soluble in the respiratory environment and is available for absorption. In the case of respiratory exposure the amount of absorbed substance plays a main role in the biological effects. Extensive bio-accessibility studies have always been an essential requirement for a better(More)
Group motility was recorded continuously in male rats during the inhalation of benzene, toluene, ethylbenzene, o-, m- and p-xylene vapours. The solvents were applied in at least six concentrations, up to those inducing anaesthesia. Minimum narcotic concentrations (ppm) were: 5940 (benzene), 3590 (toluene), 2180 (ethyl-benzene), 2180 (0-xylene), 2100(More)