Mikko S. Venäläinen

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Mechanical behavior of bone is determined by the structure and intrinsic, local material properties of the tissue. However, previously presented knee joint models for evaluation of stresses and strains in joints generally consider bones as rigid bodies or linearly elastic solid materials. The aim of this study was to estimate how different structural and(More)
Focal cartilage lesions can proceed to severe osteoarthritis or remain unaltered even for years. A method to identify high risk defects would be of utmost importance to guide clinical decision making and to identify the patients that are at the highest risk for the onset and progression of osteoarthritis. Based on cone beam computed tomography arthrography,(More)
BACKGROUND Dyslipidemia is a major modifiable risk factor for cardiovascular disease. We examined whether the addition of novel single-nucleotide polymorphisms for blood lipid levels enhances the prediction of adult dyslipidemia in comparison to childhood lipid measures. METHODS AND RESULTS Two thousand four hundred and twenty-two participants of the(More)
It is not known how inhomogeneous mechanical properties of bone affect contact mechanics and cartilage response during physiological loading of the knee joint. In this study, a finite element model of a cadaver knee joint was constructed based on quantitative computed tomography (QCT). The mechanical properties of bone were altered and their effect on(More)
The effects of fixed charge density (FCD) and cartilage swelling have not been demonstrated on cartilage mechanics on knee joint level before. In this study, we present how the spatial and local variations of FCD affects the mechanical response of the knee joint cartilage during standing (half of the body weight, 13 minutes) using finite element (FE)(More)
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