Mikko Juhani Pitkänen

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We have investigated the expression of the mRNAs for brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), neurotrophin-3 (NT-3) and neurotrophin-4 (NT-4) in the hippocampus before and after induction of long term potentiation (LTP) of synaptic transmission in the dentate gyrus through stimulation of the perforant path (PP). A unilateral PP(More)
Allowing mobile users to find and access resources available in the surrounding environment opportunistically via their smart devices could enable them to create and use a rich set of services. Such services can go well beyond what is possible for a mobile phone acting alone. In essense, access to diverse resources such as raw computational power, social(More)
The present study was undertaken to investigate the effects of modulation of the N-methyl-D-aspartate (NMDA) receptor on learning and memory. Thus, the performance of rats treated with D-cycloserine, a partial agonist at the glycine recognition site of the NMDA receptor complex, and MK-801, a noncompetitive NMDA receptor antagonist, either alone or(More)
—Delay-tolerant Networking (DTN) provides a platform for applications in environments where end-to-end paths may be highly unreliable or do not exist at all. In many applications such as distributed wikis or photo sharing, users need to be able to find content even when they do not know an unambiguous identifier. In order do bring these applications to the(More)
Delay-tolerant networking is used for communication in challenged environments such as MANETs, in which links are unstable and end-to-end paths between communicating nodes may not exist. Messages may be significantly larger than packets in IP networks. Large messages lead to longer transfer times rendering it more likely that a link breaks in the middle of(More)
1. The present study was designed to investigate whether pharmacological modulation of N-methyl-D-aspartate (NMDA) receptor function could modify hippocampal type 2 theta activity in the dentate gyrus of rats. 2. The effects of pre-recording administration of d-cycloserine (DCS: 1.0, 3.0 and 9.0 mg/kg, i.p.), a partial agonist at the NMDA receptor(More)
In the present study we investigated the effects of two competitive NMDA receptor antagonists, CGP 37849 (DL-(E)-2-amino-4-methyl-phosphono-3-pentonoic acid) and CGP 39551 (carboxyethyl ester of CGP 37849) as well as MK-801 ((+)-5-methyl-10,11-dihydro-5H-dibenz(a,d)cycloheptene-5,10-imine hydrogen maleate), a non-competitive antagonist, administered(More)
—Mobile phones are becoming commonplace for consuming Internet content and services. However, availability, affordability, and quality of the supposedly ubiquitous cellular network infrastructure may be limited, so that delay-tolerant web access via WLAN hotspots becomes an interesting alternative , even in urban areas. In this paper we explore mobile web(More)
The present study investigated the dose-dependent effects of d-cycloserine, a partial agonist at the glycine modulatory site associated with the NMDA receptor complex, on the hippocampal field potentials of dentate granule cells in awake, freely moving rats. Five sequential field potentials were recorded from the dentate gyrus of the dorsal hippocampus, by(More)