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In reproductive-age women, one of the common adverse effects of chemotherapy and radiotherapy is premature ovarian failure. In addition, a significant number of women experience early… (More)
- S. Murakami, Mikio Kan, Wallace L. Mckeehan, Benoit de Crombrugghe
- Proceedings of the National Academy of Sciences…
- 2000
Recent experiments have established that Sox9 is required for chondrocyte differentiation. Here, we show that fibroblast growth factors (FGFs) markedly enhance Sox9 expression in mouse primary… (More)
- Wallace L. Mckeehan, F. Wang, Mikio Kan
- Progress in nucleic acid research and molecular…
- 1998
The fibroblast growth factor (FGF) receptor complex is a ubiquitous regulator of development and adult tissue homeostasis that bridges the peri-cellular matrix and the intracellular environment.… (More)
- C. Yu, Fubao Wang, +5 authors Wallace L. Mckeehan
- The Journal of biological chemistry
- 2000
Heparan sulfate-regulated transmembrane tyrosine kinase receptor FGFR4 is the major FGFR isotype in mature hepatocytes. Fibroblast growth factor has been implicated in the definition of liver from… (More)
- Tetsuro Yokokawa, Mikio Kan, S. Okada, Lynne Y. Sakai
- 2008 5th International Symposium on Turbo Codes…
- 2008
We introduce a parity and column twist bit interleaver which improves performance of DVB-T2 LDPC codes in channels with erasure. The key idea is avoiding multiple bits on constellation symbols which… (More)
- S. Feng, Fubao Wang, Akemi Matsubara, Mikio Kan, Wallace L. Mckeehan
- Cancer research
- 1997
Progressive loss of the differentiated phenotype and communication with stroma accompanies the transition of nonmalignant rat prostate epithelial cells to anaplastic, malignant tumors. Here we show… (More)
- Mikio Kan, Fubao Wang, Benjaman To, Jean-Pierre Gabriel, Wallace L. Mckeehan
- The Journal of biological chemistry
- 1996
Polypeptides of the fibroblast growth factor (FGF) family are ubiquitous bioregulators within tissues whose activity is controlled by heparan sulfates within the pericellular matrix. FGF and the… (More)
- Mikio Kan, Fubao Wang, J. Xu, John W. Crabb, J. Hou, Wallace L. Mckeehan
- Science
- 1993
Heparin or heparin-like heparan sulfate proteoglycans are obligatory for activity of the heparin-binding fibroblast growth factor (FGF) family. Heparin interacts independently of FGF ligand with a… (More)
- S. Ye, Y. Luo, +7 authors Wallace L. Mckeehan
- Biochemistry
- 2001
Stromal cell-derived FGF-7 binds and activates only the resident FGFR2IIIb in epithelial cells while FGF-1 and FGF-2 exhibit a broader interaction with multiple isoforms of FGFR. Here we report the… (More)
- Mikio Kan, X Wu, Fubao Wang, Wallace L. Mckeehan
- The Journal of biological chemistry
- 1999
A divalent cation-dependent association between heparin or heparan sulfate and the ectodomain of the FGF receptor kinase (FGFR) restricts FGF-independent trans-phosphorylation and supports the… (More)