Mikio Hiura

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UNLABELLED N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-4-(11)C-methoxy-N-methylbenzamide ((11)C-ITMM) is a potential radioligand for mapping metabotropic glutamate receptor type 1 (mGluR1) in the brain by PET. The present study was performed to determine the safety, distribution, radiation dosimetry, and initial brain imaging of (11)C-ITMM in(More)
Cerebral blood flow (CBF) during dynamic exercise has never been examined quantitatively using positron emission tomography (PET). This study investigated changes in CBF that occur over the course of a moderate, steady-state cycling exercise. Global and regional CBF (gCBF and rCBF, respectively) were measured using oxygen-15-labeled water (H(2)(15)O) and(More)
INTRODUCTION Many neurotrauma patients suffer from higher brain dysfunction even when focal brain damage is not detected with MRI. We performed functional imaging with positron emission tomography (PET) to clarify the relationship between the functional deficit and symptoms of such patients. METHODS Patients who complain of higher brain dysfunction(More)
The present study examined the regional differences of cortical oxygenation in the frontal lobe by near-infrared spectroscopy (NIRS) during incremental exercise tests and the precise location of NIRS was examined by brain magnetic resonance imaging (MRI). Pulmonary gas exchange and NIRS measurement during incremental cycling ergometry tests were(More)
[Abstract] Purpose: The purpose of this study was to investigate the kinetics of cerebral blood flow (CBF) in conjunction with cardiopulmonary response during constant-work rate cycling exercise of moderate and heavy intensities. Methods: Seven subjects (6 males and 1 female; age, 25.4 ± 7.7 yr; height, 171.9 ± 4.3 cm; body mass, 67.7 ± 11.4 kg)(More)
Background Previous studies strongly have supported importance of aerobic capacity for 2000m rowing performance [1-3] and there are few studies that demonstrated anaerobic capacity had critical role in rowing performance [4-6]. The purpose of the present study is to investigate the relationship between 2000m rowing performance and anaerobic capacity, which(More)
The central opioid receptor system likely contributes to the mechanism underlying the changes in affect elicited by exercise. Our aim was to use positron emission tomography (PET) to test whether exercise intensity influences activation of the μ-opioid receptor system in the brain, and whether changes in opioid receptor activation correlate with(More)
Previous studies demonstrated that cerebral blood flow (CBF) changes during dynamic exercise and a physiological basis for this observation may be explained by the tight control of CBF by arterial carbon dioxide tension (PaCO2). This study examined whether the steady state of the middle cerebral artery blood flow velocity (MCAVmean) and PaCO2 could be(More)
The authors herein report the case of a young male with memory deficits due to a traumatic head injury, who presented with sleep-related symptoms such as hypersomnia and dream alterations. Although MRI and polysomnography showed no abnormalities, (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) and (11)C flumazenil (FMZ)-PET revealed findings(More)