Mikihito Shibata

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noncoding variants can be challenging to intuit8. Therefore, to understand disease mechanisms, it is necessary to perform comprehensive analyses of the regulatory regions, epigenetic modifications and gene expression patterns present across different ages, regions and cell types in both the healthy and the disease-affected human CNS. Unfortunately, so far,(More)
Transcriptional mechanisms mediated by the binding of transcription factors (TFs) to cis-acting regulatory elements (CREs) in DNA play crucial roles in directing gene expression. While TFs have been extensively studied, less effort has gone towards the identification and functional characterization of CREs and associated epigenetic modulation. However,(More)
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