Mikhail P Panchenko

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The betagamma subunits of the heterotrimeric GTP-binding proteins (G proteins) that couple heptahelical, plasma membrane-bound receptors to intracellular effector enzymes or ion channels directly regulate several types of effectors, including phospholipase Cbeta and adenylyl cyclase. The beta subunit is made up of two structurally different regions: an(More)
We have previously reported that neutrophil elastase (NE) downregulates transforming growth factor-(TGF-) maintained tropoelastin mRNA levels in lung fibroblasts through transactivation of the epidermal growth factor receptor (EGFR)/Mek/Erk pathway, which is dependent on the NE-initiated release of soluble EGFR ligands. In the present study, we investigated(More)
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