Mikhail Davydov

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Recent experimental studies revealing new biological effects of tamoxifen on tumor cells both expressing and not expressing different types of estrogen receptors (ERα and ERβ) show new aspects of a seemingly well known agent. This review describes tamoxifen targets, the blocking of which leads to inhibition of tumor cell growth and angiogenesis, stimulation(More)
141 Platinum drugs are a group of anticancer drugs most widely used in clinical practice. However, their effectiveness varies significantly not only depending on the type of tumor and severity of disease, but also from one patient to another, with the same clinicoo pathologic signs. This variation is caused by the molecular characteristics of the tumor, in(More)
Using the model of breast cancer Ehrlich ascites tumor in mice, we showed that a sigle intraperitoneal injection of cardiac glycoside digoxin 1 h before the intraperitoneal injection of cisplatin increased the anticancer effect of the cytostatic drug more than twice when recalculated for the dose. It is assumed that the modifying effect of digoxin is(More)
29 Nonnsmall cell lung carcinoma (NSCLC) is one of the most severe cancers with adverse outcome; the results of its treatment cannot be regarded as satisfacc tory. Therefore, the search for pathogenetically grounded and patienttcentered approaches to the treatment of NSCLC is undoubtedly one of the top priorities. In our opinion, discovery of a new class of(More)
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