Mikelis G. Bickis

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Tamoxifen treatment substantially improves the 10-year survival of women with estrogen-receptor (ER)-alpha-positive tumors. However, approximately one-third of all breast cancer patients with ER-alpha-positive tumors progress on antiestrogen therapy. The molecular mechanism(s) involved in antiestrogen-resistant phenotype of breast carcinoma is not(More)
A pilot study using female cynomolgus (Macaca fascicularis) and female rhesus (Macaca mulatta) monkeys was conducted to study the effects of chronic ingestion of polychlorinated biphenyls (PCBs). Four control and four treated monkeys of each species received an apple juice-gelatin mixture containing 0 and 280 micrograms Aroclor 1254/kg body weight/day,(More)
Two studies were conducted with weanling male rodents in an attempt to ascertain more precisely the toxic effects of deoxynivalenol (DON). In a feeding study of approximately 18-wk duration, groups of 90 Swiss-Webster derived mice and 50 Sprague-Dawley rats were fed a commercial chow (118 ppb DON), and groups of 80 mice and 50 rats were fed either an(More)
Hidden Markov models (HMMs) are one of various methods that have been applied to prediction of major histo-compatibility complex (MHC) binding peptide. In terms of model topology, a fully-connected HMM (fcHMM) has the greatest potential to predict binders, at the cost of intensive computation. While a profile HMM (pHMM) performs dramatically fewer(More)
We study the usage of specific peptide platforms in protein composition. Using the pentapeptide as a unit of length, we find that in the universal proteome many pentapeptides are heavily repeated (even thousands of times), whereas some are quite rare, and a small number do not appear at all. To understand the physico-chemical-biological basis underlying(More)
Alignment of protein sequences is fundamental in analyzing homology, evolutionary events and functional relationships. Searching for the epitopic peptide platform underlying hepatitis C virus (HCV) infection and autoimmune phenomena, we have used sequence-sequence peptide matching to compare the HCV polyprotein sequence to the human proteome. The following(More)
Desmopressin and ethamsylate were evaluated for possible synergistic effects on the bleeding time. The drugs were administered individually and together to 12 patients with markedly prolonged bleeding times known to be relatively or absolutely unresponsive to desmopressin alone. The bleeding disorders studied included Glanzmann's thrombasthenia (one), other(More)
Fecal samples were collected systematically in the spring from cows and yearlings entering, and in the fall from calves leaving, five community pastures in central Saskatchewan. Fecal samples were also collected systematically in the spring from cows entering, and in the fall from calves leaving, an experimental rotational grazing system. Samples were(More)
One-armed bandit processes with continuous delayed responses are formulated as controlled stochastic processes following the Bayesian approach. It is shown that under some regularity conditions, a Gittins-like index exists which is the limit of a monotonic sequence of break-even values characterizing optimal initial selections of arms for finite horizon(More)
Cayley’s hyperdeterminant is a homogeneous polynomial of degree 4 in the 8 entries of a 2×2×2 array. It is the simplest (nonconstant) polynomial which is invariant under changes of basis in three directions. We use elementary facts about representations of the 3-dimensional simple Lie algebra sl2(C) to reduce the problem of finding the invariant polynomials(More)