Mike Wigler

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Research in the our lab is divided into three efforts. The first and oldest part is the study of Ras signal transduction pathways. Mutant Ras were the first hu­ man oncogenes discovered, and homologs of the Ras genes are found throughout eukaryotic evolution. Our original and major objective was to understand the targets of these small GTPases, but now that(More)
Our group uses methods for comparative genome analy­ sis to study cancer and human genetic disorders. New mutations, somatic and germline, underlie the cancers and human genetic disorders. Our main focus to date has been studying mutations that change the numbers of copies of sections of the genome, causing regions of deletion and duplication, in cancer and(More)
Eukaryotic cells carry two genomes, nuclear (nDNA) and mitochondrial (mtDNA), which are ostensibly decoupled in their replication, segregation and inheritance. It is increasingly appreciated that heteroplasmy, the occurrence of multiple mtDNA haplotypes in a cell, plays an important biological role, but its features are not well understood. Accurately(More)
are a hallmark of many human cancers (Balmain et al. 2003; DePinho and Polyak 2004), reflecting the evolution of the tumor and its ability to proliferate and spread within the host. Breast tumors in particular exhibit a wide range of karyotypic changes including duplication or loss of multiple chromosome arms or entire chromosomes, along with a variety of(More)
Correspondence: ravi.mssm@gmail.com Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai , One Gustave L. Levy place, New York, 10029, USA Full list of author information is available at the end of the article Abstract Eukaryotic cells carry two genomes, nuclear (nDNA) and mitochondrial (mtDNA), which are ostensibly decoupled in their(More)
We study variations in the human genome that arise when a large segment of the genome is duplicated or deleted. Such copy-number variations, or CNVs, can arise somatically or in the germ line. The former are often seen in cancer and distinguish cancers from the normal cells of the body, in which case, they provide clues for the origin and behavior of the(More)
60 ulated by at least fivefold, and 60 similarly down-regulated genes. Among those that increased are neuron-associated genes such as APP and neuronal protein 3.1, and genes associated with tissue remodeling (proteinases and inhibitors). Many of the affected genes are unannotated expressed sequence tags (ESTs), and these experiments will contribute to an(More)
Correspondence: ravi.mssm@gmail.com Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai , One Gustave L. Levy place, New York, 10029, USA Full list of author information is available at the end of the article Abstract Eukaryotic cells carry two genomes, nuclear (nDNA) and mitochondrial (mtDNA), which are ostensibly decoupled in their(More)
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