Mike Tabriz

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Introduction: In our laboratories we have developed [C]LY2795050 as a novel, selective antagonist tracer for the kappa opioid receptor (KOR). Imaging studies in rhesus monkeys have demonstrated the tracer's suitability to image KOR in vivo. Thus, a first-in-human study was conducted to evaluate the potential of this novel tracer for PET imaging of KOR in(More)
Glycine transporter type-1 (GlyT1) has been proposed as a target for drug development for schizophrenia. PET imaging with a GlyT1 specific radiotracer will allow for the measurement of target occupancy of GlyT1 inhibitors, and for in vivo investigation of GlyT1 alterations in schizophrenia. We conducted a comparative evaluation of two GlyT1 radiotracers,(More)
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