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BACKGROUND PreImplantation Factor (PIF), a novel peptide secreted by viable embryos is essential for pregnancy: PIF modulates local immunity, promotes decidual pro-adhesion molecules and enhances trophoblast invasion. To determine the role of PIF in post-fertilization embryo development, we measured the peptide's concentration in the culture medium and(More)
If planning for a large co-located 30-plus development team is not enough to make you want to pull your hair out then try a 30-plus development team located across several time zones, in places with different cultures and languages. Now, you’ve reached a level in the Agile planning game that would send most product owners running home to their mommies.(More)
Preimplantation factor (PIF) is secreted by viable mammalian embryos and promotes implantation and trophoblast invasion. Whether PIF also has a direct protective or promoting effect on the developing embryo in culture is unknown. This study examined the protective effects of synthetic PIF (sPIF) on embryos cultured with embryo toxic serum (ETS) from(More)
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