Mike Sharkey

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Lovastatin therapy is known to induce hepatic low density lipoprotein (LDL) receptor mRNA and LDL receptor activity. Yet, in studies in humans and animals it has been difficult to demonstrate an enhancement of the plasma fractional catabolic rate (FCR) of an injected LDL tracer during lovastatin therapy. One explanation may be that the composition of the(More)
Familial hypercholesterolemia is caused by a genetic deficiency of the low density lipoprotein (LDL) receptor. The Watanabe heritable hyperlipidemic (WHHL) rabbit, which is also defective in LDL receptor activity, provides an excellent animal model of homozygous familial hypercholesterolemia. As a step toward development of effective gene therapy for(More)
We have reported the use of a retroviral vector to introduce the low density lipoprotein (LDL) receptor gene into receptor-deficient Watanabe heritable hyperlipidemic (WHHL) rabbit fibroblasts (Miyanohara, A., M. F. Sharkey, D. Steinberg, J. L. Witztum, and T. Friedmann. 1988. Proc. Natl. Acad. Sci. USA. 85: 6538-6542). Because the cDNA for the LDL receptor(More)
The goal of this shared task was to predict attrition in a MOOC through use of the data and logs generated by the course. Our approach to the task reinforces the idea that the process of gathering and structuring the data is more important (and more time consuming) than the predictive model itself. The result of the analysis was that a subset of 15(More)
The question posed by the 2014 LAK Data Challenge is " What do analytics on learning analytics tell us? " The authors looked to take a two-pronged approach to this challenge. First, the authors wanted to use advanced analytical techniques on the corpus to make the " eat your own dog food " point. Since many of the EDM/LAK submissions explain advanced(More)
Gaucher's disease is an autosomal recessive lysosomal storage disease, resulting from a deficiency of the enzyme glucocerebrosidase, important for the physiologic recycling of cell membrane lipids. The clinical symptoms and disease presentations of Gaucher's disease are heterogeneous, including hepatosplenomegaly, bone "crisis" and fracture, anemia,(More)
We report the case of a patient who presented with new onset of dysphagia for solids and liquids. Her condition was subsequently diagnosed as sarcoidosis on the basis of granulomatous inflammation in tissue obtained from transbronchial fine needle aspiration, noncaseating granulomas in a full-thickness lip biopsy, mild uveitis on slit lamp examination, and(More)