Mike Selby

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BACKGROUND Metastasis formation in colon cancer severely reduces the survival rate in patients. S100A4, a calcium-binding protein, is implicated in promoting metastasis formation in colon cancer. METHODS To identify a transcription inhibitor of S100A4, high-throughput screening of 1280 pharmacologically active compounds was performed using a human colon(More)
Hypoxia-inducible factor 1 (HIF-1) is a master regulator of the transcriptional response to oxygen deprivation. HIF-1 has been implicated in the regulation of genes involved in angiogenesis [e.g., vascular endothelial growth factor (VEGF) and inducible nitric oxide synthase] and anaerobic metabolism (e.g., glycolytic enzymes). HIF-1 is essential for(More)
The calcium-binding protein S100A4 is a central mediator of metastasis formation in colon cancer. S100A4 is a target gene of the Wnt/β-catenin pathway, which is constitutively active in the majority of colon cancers. In this study a high-throughput screen was performed to identify small-molecule compounds targeting the S100A4-promoter activity. In this(More)
Hypoxia-inducible factor 1 (HIF-1) is a master regulator of the tran-scriptional response to oxygen deprivation. HIF-1 has been implicated in the regulation of genes involved in angiogenesis [e.g., vascular endothelial growth factor (VEGF) and inducible nitric oxide synthase] and anaerobic metabolism (e.g., glycolytic enzymes). HIF-1 is essential for(More)
The NCI60 cell line panel screen includes 60 human tumor cell lines derived from nine tumor types that has been used over the past 20+ years to screen small molecules, biologics, and natural products for activity. Cells in monolayer culture in 96-well plates are exposed to compounds for 48 h, and Sulforhodamine B is used to determine cell viability. Data(More)
For many decades, the number of minority students, particularly Hispanics, dropping out from school has been noticeable to say the least (Rumberger, 1995). These students have in the past and continue in the present to struggle with the educational system, and it is certain, but not clear, that various factors contribute to Hispanics' poor academic(More)
A presentation of a hot, new creationist video. Here's what the producers have to say: " Unlocking the Mystery of Life is the story of contemporary scientists who are advancing a powerful, but controversial, idea —the theory of 'intelligent design.' " We shall see! This meeting is free and open to the public. Phone 214-335-9248 for information. E arly in(More)
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