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Measurement of brain atrophy has been proposed as a surrogate marker in MS and degenerative dementias. Although cerebral small vessel disease predominantly affects white and subcortical grey matter, recent data suggest that whole brain atrophy is also a good indicator of clinical and cognitive status in this disease. Automated methods to measure atrophy are(More)
BACKGROUND AND PURPOSE Cerebral atrophy has been recently recognized as a key marker of disease progression in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). The contribution of subcortical cerebral lesions in this process remains undetermined. The aim of this study was to investigate the relationships(More)
Brain atrophy represents a key marker of disease progression in cerebrovascular disorders. The 3D changes of cortex morphology occurring during the course of small vessel diseases of the brain (SVDB) remain poorly understood. The objective of this study was to assess the changes affecting depth and surface area of cortical sulci and their clinical and(More)
Recent evidence suggests that hippocampal changes are present in vascular cognitive impairment but their importance and relationship with ischaemic mechanisms remain controversial. To investigate these issues we performed MRI and cognitive assessment in a large cohort (n=144) of patients with CADASIL, a hereditary small vessel disease and model of pure(More)
See related article, pages 000 – 000. I n this issue of Stroke, Reitz and coworkers explore the link between incident stroke and dementia in data from the Rotterdam Study. 1 The emphasis on incident stroke is important: previous studies to address this question have recruited patients at the time of stroke so that prestroke cognitive status has been(More)
The patency of the upper airway is dependent on the sustained activity of upper airway muscles, in particular the genioglossus (GG) muscles which act to protrude the tongue. Obstructive sleep apnea syndrome (OSAS) is a common and serious disorder in which this mechanism fails, resulting in frequent collapse of the airway during sleep. The properties of the(More)
To gauge the impact of screening mammography and opinions regarding surgical procedures on the pattern of primary surgical care of breast cancer, tumor registry statistics from 1980-81 were compared to those from 1987 at a large community hospital. Over the course of six years, there was a significant increase in the proportion of patients with smaller(More)
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