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Recent advances in the structure-activity relationships of substituted corticosteroids.
Abstract The influence of the 6-azido-6-ene grouping on corticosteroid activity has been studied. The 6-azido-6-ene-corticosteroids were synthesized by reaction of the methanesulfonate esters ofExpand
  • 5
The effects of a nonsteroid antiandrogen, flutamide, on sebaceous gland activity.
Flutamide (alpha,alpha,alpha-trifluoro-2-methyl-4'-nitro-m-propionotoluidide), at daily oral doses of 20 mg/day for 24 days, reduced the number and size of skin sebaceous gland cells, and reducedExpand
  • 41
Synthesis and topical antiinflammatory activity of some steroidal [16 alpha, 17 alpha-d]Isoxazolidines.
  • 30
Selective effects of 7 alpha-halogeno substitution on corticosteroid activity: Sch 22219 and Sch 23409.
Two 7 alpha-halogeno substituted corticosteroids, 7 alpha-chloro-16 alpha-methylprednisolone-17,21 dipropionate (Sch 22219) and 7 alpha-bromo-16 alpha-methylprednisolone-17-benzoate-21-acetate (SchExpand
  • 7
Synthesis and structure-activity studies of a series of 7 alpha-halogeno corticosteroids.
The preparation and topical antiinflammatory potencies of a series of 7 alpha-halogeno-16-substituted-prednisolone derivatives are described. The 7 alpha-chloro, 7 alpha-bromo, and 7 alpha-iodoExpand
  • 8
Synthesis and structure-activity relationships in a novel series of topically active corticosteroids.
Abstract The influence of 7α-halogeno substitution on topical anti-inflammatory potency was studied in a series of prednisolone derivatives. 7α-Chloro, bromo and iodocorticosteroids were synthesizedExpand
  • 6
The influence of esterification on the topical antiinflammatory activity of 7 alpha-chloro- and 7 alpha-bromo-16 alpha-methylprednisolones.
The effect on topical antiinflammatory potency of altering the ester functions of 7-halogenocorticosteroids was examined. Highest potencies for both 7 alpha-chloro- and 7 alpha-bromo-16Expand
  • 1
Synthesis and topical antiinflammatory potencies of a series of 6-keto- and delta 6-6-acyloxybetamethasone derivatives.
6-keto- and delta 6-6-acyloxybetamethasone esters were synthesized, and tested for topical antiinflammatory potency using a modification of the Tonelli croton ear assay. The introduction of a 6-ketoExpand
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