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Macrophages have many functions in development and homeostasis as well as innate immunity. Recent studies in mammals suggest that cells arising in the yolk sac give rise to self-renewing macrophage populations that persist in adult tissues. Macrophage proliferation and differentiation is controlled by macrophage colony-stimulating factor (CSF1) and(More)
tary endocrine cell size and consequently hormone secretion. We have previously shown that lentiviral vectors can be used to generate transgenic chickens efficiently and that expression of introduced transgenes is not silenced on transmission through the germline. Transgene expression can be targeted in the predicted tissue-restricted manner, for example:(More)
pathway contributes to the heterogeneous differentiation potential of ES cells. Primordial germ cells (PGCs) are the precursors of the germ cell lineage. A method for the prolonged invitro culture of chicken PGCs, which retain the ability to colonise the gonad when introduced into developing embryos, has been described (van de Lav-oir etal., Nature 441(More)
slower clocks such as the mouse. Our analyses of early neurogenesis in several representatives of chelicerates (e.g. spiders) and myriapods (e.g. millipedes) have revealed that the genetic network involved in recruitment and specification of neural precursors is conserved in all euarthropod groups. However, the expression pattern and function of these genes(More)
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