Mike Lichten

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Checkpoint gene function prevents meiotic progression when recombination is blocked by mutations in the recA homologue DMC1. Bypass of dmc1 arrest by mutation of the DNA damage checkpoint genes MEC1, RAD17, or RAD24 results in a dramatic loss of spore viability, suggesting that these genes play an important role in monitoring the progression of(More)
In Escherichia coli, mutagenesis by agents such as ultraviolet light, methyl methanesulfonate and 4-nitroquinoline-1-oxide is not a passive process. Rather, it requires the intervention of a cellular system that processes damaged DNA in such a way that mutations result. This type of processing is referred to as "error prone repair". This process can be(More)
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