Mike Leggett

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CYP51 sterol demethylases are the only cytochrome P450 enzymes with a conserved function across the animal, fungal, and plant kingdoms (in the synthesis of essential sterols). These highly conserved enzymes, which are important targets for cholesterol-lowering drugs, antifungal agents, and herbicides, are regarded as the most ancient member cytochrome P450(More)
BACKGROUND A modification of a standard method of fluorescence in situ hybridisation (FISH) is described, by which a combination of several substrates and probes on single microscope slides enables more accurate comparisons of the distribution and abundance of chromosomal sequences and improves the relatively low throughput of standard FISH methods. (More)
This paper will examine the concept of ‘data space’ and sentient ‘presence’ in relation to practice-based research being pursued by myself and others working in the institutional space that lies between the disciplines of art and science. It will consider the broader Western cultural context for the idea of presence and the contemporary literature produced(More)
The contemporary burgeoning usage of digital movies, photos, audio and text, their distribution through networks both electronic and physical, will be considered in the context of a convergence of these media with a contemporary engagement with personal and community history.An interactive experimental prototype, PathScape, will be described and evaluated(More)
The contemporary burgeoning usage of digital movies, photos, audio and text, their distribution through networks both electronic and physical will be considered in the context of a convergence of these media with a popular interest in personal and community history and identity.The paper introduces interdisciplinary research into human memory as a context(More)
In this paper we propose the exploitation of high mobility portable battery operated video players (PVP) for the retrieval of video associated with the location in which it may be used. Reporting on an earlier interactive multimedia location-based prototype, we assess the possibilities for specific ontologies of a taxonomy of indexing procedure which avoids(More)
A series of Models were built to explore and test the precept of navigating movies using gesture to control both forward and backward movement, and to launch movie files linked using visual elements associatively and semantically related to the knowledge domain represented within a movie collection.
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