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Hypoxia (0% O2) evokes a late-phase, endothelium-dependent contractile response in porcine isolated pulmonary arteries that may be caused by a cyclooxygenase-independent, endothelium-derived contractile factor. The aim of this study was to further analyze the mechanism underlying this hypoxic response. Proximal porcine pulmonary arterial rings were(More)
The aim of this study was to characterize the mechanisms underlying pulmonary vascular dysfunction after cardiopulmonary bypass (CPB) by examining responses of isolated pulmonary arteries to selective endothelium-dependent and -independent activators in control and post-CPB dogs. Adult male mongrel dogs were placed on closed-chest, hypothermic CPB for 2.5(More)
The aim of this study was to characterize the alpha-adrenoceptors of the canine pulmonary artery. Arterial rings from lower lung lobes were suspended for isometric-tension recording in the presence of cocaine (5 x 10(-6) M), hydrocortisone (3 x 10(-5) M), propranolol (5 x 10(-6) M), and rauwolscine (10(-7) M) to inhibit neuronal uptake, extraneuronal(More)
A final report of RISE: RTOs in the service economy-Knowledge infrastructures, innovation intermediaries and institutional change RISE reports may be downloaded from: Abstract Chapter 1 Introduction-RTOs, actual and stereotypical, diverse Appx 1 RTOs, government and governance Appx 2 RTOs as suppliers in a hybrid economy of tacit and explicit innovation(More)
Sympathotonic orthostatic hypotension (SOH) is an idiopathic syndrome characterized by tachycardia, hypotension, elevated plasma norepinephrine, and symptoms of orthostatic intolerance provoked by assumption of an upright posture. We studied a woman with severe progressive SOH with blood pressure unresponsive to the pressor effects of alpha(1)-adrenergic(More)