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Fluid secretion is essential for intestinal function and, in eutherian mammals, is driven by electrogenic Cl(-) transport, which is dependent upon a bumetanide-sensitive, basolateral Na(+)/K(+)/2 Cl(-) cotransporter, NKCC1. However, ileal secretion in the brushtail possum, a marsupial, involves a fundamentally different process, since NKCC1 expression is(More)
The colon of the brushtail possum does not have an electrogenic secretory response. Given the functional significance of electrogenic Cl− secretion in the intestine of eutherian mammals, we have investigated the secretory response in the small intestine of this marsupial. In the Ussing chamber cAMP-dependent secretagogues stimulated a sustained increase in(More)
OBJECTIVE To compare trends in the numbers of people with serious traffic injuries according to police statistics and hospital episode statistics (HES). DESIGN Descriptive study based on two independent population based data sources. SETTING Police statistics and hospital episode statistics in England. MAIN OUTCOME MEASURES Rates of injury and death(More)
Fel-O-Vax FIV is an inactivated virus vaccine designed as an aid in the prevention of infection of cats, 8 weeks or older, by feline immunodeficiency virus (FIV). It contains two genetically distinct FIV strains. The efficacy of this vaccine was demonstrated in a vaccination-challenge study designed to meet various regulatory requirements for registering(More)
In eutherian mammals, fluid secretion is essential for intestinal function. This is driven by electrogenic Cl(-) secretion, which involves a NaK2Cl cotransporter (NKCC1) in the enterocyte basolateral membrane and the cystic fibrosis transmembrane conductance regulator (CFTR) in the apical membrane. However, in the possum ileum, NKCC1 expression is low and(More)
A simulation exercise intended to ease the development of clinical networks found that primary care trusts were eager to co-operate with one other. Acute trusts emerged as the most confident 'players'; they were perceived as a 'provider cabal' by PCTs. Participants felt the legacy of the internal market might have impeded joint-working across trusts. The(More)