Mike G Falcon

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This paper describes three siblings, the only affected members of the family, with gelatinous drop-like keratopathy. This rare form of primary corneal amyloidosis has been reported almost exclusively in Japanese literature, and to our knowledge this is the first report of the condition seen in the United Kingdom. Clinical and histological details are(More)
PURPOSE To report 5 cases of high astigmatism after penetrating keratoplasty (PK) treated with corneal wedge excisions. METHODS We report our experience of 5 patients treated with corneal wedge excisions for high astigmatism after PK. A thin sliver of cornea measuring between 0.1 and 0.2 mm in thickness was excised from just inside the graft-recipient(More)
Acycloguanosine (9-[-hydroxyethoxymethyl]guanine) (Wellcome 248U) has a highly specific and potent antiviral action against herpes-simplex virus (H.S.V.) types I and II in cell-culture systems and in animal models of H.S.V. infection in the brain, skin, and eye. Its efficacy in man was tested in twenty-four patients with dendritic corneal epithelial ulcers(More)
55 patients with dendritic ulcer have been treated in a double-blind randomised manner by minimal wiping debridement of their ulcers followed by daily application of either partially purified human interferon (P.I.N.F.) or placebo. There were 6 recurrences of epithelial herpetic disease in 30 patients who received P.I.N.F. and 13 in 25 who received placebo.(More)
Clinical features of 152 patients with herpetic keratitis after a five-year observation period were analyzed. When compared with dendritic ulceration, geographic ulcers that had been symptomatically present for a longer time were more likely to have been treated with a topical steroid and took longer to heal. After treatment of the corneal ulceration, 40%(More)
Intraocular lens implant components such as dialling holes can cause disabling symptoms when decentration of the implant places these components in the pupil. In order to investigate the importance of optic size in this context, we studied two groups of consecutive patients who had undergone cataract surgery: one group had received an implant with a 6 mm(More)
  • M G Falcon
  • 1983
Herpetic keratitis remains a prominent cause of recurrent or chronic and blinding corneal disease; areas of particular difficulty are indolent ulceration, herpetic keratouveitis, keratoplasty and problems associated with steroid therapy. Topical acyclovir has been widely demonstrated to be a safe and effective antiviral for ulcerative herpetic keratitis;(More)
  • M G Falcon
  • 1987
Acyclovir has been widely used against the various manifestations of eye disease due to herpes simplex since it first became generally available in the UK nearly five years ago. This paper discusses the rational indications for its use, through considerations of its pharmacology and pharmacokinetics, and through results of the many clinical trials that have(More)