Mike Franklin

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Extracts of Hypericum perforatum (HP) have been shown to be effective for the treatment of mild to moderate depression. Its mode of action has not been fully elucidated. An increase in plasma and cerebrospinal fluid (CSF) cortisol is frequently observed in depression. Studies have suggested that HP might alter brain cortisol and corticosterone through its(More)
BACKGROUND St John's wort is an effective antidepressant that can reduce tobacco withdrawal symptoms, but it is not known whether it assists cessation. Chromium assists weight loss and might limit post cessation weight gain. METHODS In a factorial design, we randomised smokers stopping smoking to 900 mg St John's wort (SJW) active or placebo and also(More)
Information fragmentation is a pervasive problem which is felt in several stages of personal information management (PIM). As the example in the introduction to this special issue on PIM illustrates, even a seemingly simple decision, such as whether to say “yes” to an invitation, often depends upon a number of different kinds of information – information(More)
Database needs are changing, driven by the Internet and increasing amounts of scientific and sensor data. In this article, the authors propose research into several important new directions for database management systems. A group of senior database researchers gathers every few years to assess the state of database research and to point out problem areas(More)
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