Mike Engle

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The study of signal transduction processes using antisense oligonucleotides is often complicated by low intracellular stability of the antisense reagents or by nonspecific effects that cause toxicity. Here, we introduce a new class of antisense molecules, so-called GeneBlocs, which are characterized by improved stability, high target RNA specificity, and(More)
Mulitsensor data fusion (MSDF) has been researched for decades yet programs relying on it to provide a situational, or threat, assessment continue to be less than successful. In order to alleviate the too-much-information, too-fewanalysts issue, a better approach must be determined. A survey of recent and current data fusions programs was conducted along(More)
The use of protein crystals to determine the detailed molecular structures of proteins is a common laboratory technique used by biochemists throughout the world. While a variety of techniques and approaches may be used to produce crystals of proteins, one requirement is common to all structural studies using protein crystals--the need to have large, well(More)
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