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The study of signal transduction processes using antisense oligonucleotides is often complicated by low intracellular stability of the antisense reagents or by nonspecific effects that cause toxicity. Here, we introduce a new class of antisense molecules, so-called GeneBlocs, which are characterized by improved stability, high target RNA specificity, and(More)
MSDF programs have long been a goal of the DoD and the warfighter. It promises to combine information from multiple sensors in order to determine what traditionally could not be determined by one sensor alone either because of technological limitations or geographic restrictions. These multisensor systems can be used to increase geolocation accuracy, reduce(More)
  • M Engle
  • 1993
The use of protein crystals to determine the detailed molecular structures of proteins is a common laboratory technique used by biochemists throughout the world. While a variety of techniques and approaches may be used to produce crystals of proteins, one requirement is common to all structural studies using protein crystals--the need to have large, well(More)
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