Mike Cooklin

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The impedance to current flow in the intracellular compartment of guinea pig left ventricular myocardium was measured at 20 degrees C and 37 degrees C using tissue from hypertrophied hearts subjected to aortic constriction. Alternating current of varying frequency was passed longitudinally along myocardial preparations, which revealed two time constants:(More)
BACKGROUND  Cardiac resynchronization therapy (CRT) device and coronary sinus (CS) lead extraction is required due to the occurrence of system infection, malfunction, or upgrade. Published series of CS lead extraction are limited by small sample sizes. We present a 10-year experience of CRT device and CS lead extraction. METHODS  All lead extractions(More)
PURPOSE The electrical impedance of detrusor smooth muscle strips to alternating current has been measured to calculate the resistance of the intracellular pathway, in particular gap junction resistance. Values have been compared with myocardium, which is electrically well-coupled. MATERIALS AND METHODS Alternating current was passed along the(More)
The passive and active electrical properties of left ventricular myocardium were measured, using conducted action potentials and current clamp of isolated myocytes. The objective was to quantify changes of intracellular resistivity, Ri, during hypertrophic growth and the simultaneous imposition of cellular hypoxia. Ri was estimated from the time course of(More)
Atrial fibrillation (AF) is the most commonly encountered arrhythmia that occurs after cardiothoracic surgery. It develops in up to 40% of patients, most frequently in the first few postoperative days. The strongest risk factors for AF are age and male gender. The pathogenesis of this arrhythmia probably involves increased sympathetic activity in the(More)
The motion and deformation of catheters that lie inside cardiac structures can provide valuable information about the motion of the heart. In this paper we describe the formation of a novel statistical model of the motion of a coronary sinus (CS) catheter based on principal component analysis of tracked electrode locations from standard mono-plane x-ray(More)
We present a robust method to register three-dimensional echocardiography (echo) images to magnetic resonance images (MRI) based on anatomical features, which is designed to be used in the registration pipeline for overlaying MRI-derived roadmaps onto two-dimensional live x-ray images during cardiac catheterization procedures. The features used in image(More)
BACKGROUND The rising number of device implantation has seen a parallel in the rising numbers of lead extraction. Herein we have analysed our experience in cardiac device and lead extraction in a single tertiary centre over the last decade. METHOD Retrospective analysis of all consecutive patients undergoing lead extractions performed between 2001 and(More)
BACKGROUND Implantable cardioverter-defibrillator function is critically dependent on reliable sensing of intracardiac signals. Lead systems that use integrated sensing, in which the distal shocking coil is part of both the sensing and shocking pathways, may be prone to undersensing of ventricular fibrillation, especially during redetection after a failed(More)
OBJECTIVES The purpose of this study was to compare transvenous atrial defibrillation thresholds with lead configurations consisting of an active left pectoral electrode and either single or dual transvenous coils. BACKGROUND Low atrial defibrillation thresholds are achieved using complex lead systems including coils in the coronary sinus. However, the(More)