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Metadata for the World Wide Web is important, but metadata for Peer-to-Peer (P2P) networks is absolutely crucial. In this paper we discuss the open source project Edutella which builds upon metadata standards defined for the WWW and aims to provide an RDF-based metadata infrastructure for P2P applications, building on the recently announced JXTA Framework.(More)
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The use of vascular intersection aberration as one of the signs when monitoring and diagnosing diabetic retinopathy from retina fundus images (FIs) has been widely reported in the literature. In this paper, a new hybrid approach called the combined cross-point number (CCN) method able to detect the vascular bifurcation and intersection points in FIs is(More)
Mycobacterium tuberculosis glutamine synthetase (MtGS) is a promising target for antituberculosis drug discovery. In a recent high-throughput screening study we identified several classes of MtGS inhibitors targeting the ATP-binding site. We now explore one of these classes, the 2-tert-butyl-4,5-diarylimidazoles, and present the design, synthesis, and X-ray(More)
Meta-data is the fundamental building block of the Semantic Web. However , the meta-data concept is too loosely defined to provide architectural guidelines for its use. This paper analyzes important uses of meta-data in the e-learning domain, from a pedagogical and philosophical point of view, and abstracts from them a set of fundamental architectural(More)
Given the prevalence of relapsing fever (RF) in Senegal, this disease may cause illness and death in other areas of West Africa. We performed a cross-sectional, clinic-based study to investigate the presence of RF in Togo during 2002-2004. Blood samples from patients with fever were examined for RF spirochetes by microscopy, PCR, and DNA sequencing of(More)
Transforming growth factor beta (TGF-β) plays major roles in tumorigenesis by regulating cell growth, epithelial-to-mesenchymal transition (EMT), migration/invasion and metastasis. The epithelial markers E-cadherin, claudin-3 and claudin-4, commonly decreased in human adenocarcinomas are actually up regulated during ovarian carcinogenesis. In human ovarian(More)
Most of today's generic annotation tools for semantic web metadata (RDF) are designed for experts. People with no or little knowledge about RDF are therefore forced to use simplified and often domain-specific tools that work with fixed sets of metadata elements. This paper introduces the Annotation Profile Model as a configuration mechanism from which(More)
Simple Temporal Networks with Uncertainty (STNUs) allow the representation of temporal problems where some durations are determined by nature, as is often the case for actions in planning. As such networks are generated it is essential to verify that they are dynamically controllable – executable regardless of the outcomes of uncontrollable durations – and(More)