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Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
We revise and renew the “MISEV2014” guidelines for studies of extracellular vesicles based on evolution of the collective knowledge in the last four years. Expand
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Dry age-related macular degeneration: mechanisms, therapeutic targets, and imaging.
Age-related macular degeneration is the leading cause of irreversible visual dysfunction in individuals over 65 in Western Society. Patients with AMD are classified as having early stage diseaseExpand
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Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration
&NA; Microglia from different nervous system regions are molecularly and anatomically distinct, but whether they also have different functions is unknown. We combined lineage tracing, single‐cellExpand
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Roles of exosomes in the normal and diseased eye
&NA; Exosomes are nanometer‐sized vesicles that are released by cells in a controlled fashion and mediate a plethora of extra‐ and intercellular activities. Some key functions of exosomes includeExpand
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Proteolytic cleavage and shedding of the bovine prion protein in two cell culture systems.
We have compared the processing, turnover and release of bovine PrP (boPrP) in transfected baby hamster kidney (BHK) and mouse neuroblastoma (N2a) cells. In BHK cells, boPrP was subjected to twoExpand
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Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration
Inherited retinal degenerations, affecting more than 2 million people worldwide, are caused by mutations in over 200 genes. This suggests that the most efficient therapeutic strategies would beExpand
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Expression of human complement factor H prevents age-related macular degeneration-like retina damage and kidney abnormalities in aged Cfh knockout mice.
Complement factor H (CFH) is an important regulatory protein in the alternative pathway of the complement system, and CFH polymorphisms increase the genetic risk of age-related macular degenerationExpand
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Unusual cerebral vascular prion protein amyloid distribution in scrapie-infected transgenic mice expressing anchorless prion protein
BackgroundIn some prion diseases, misfolded aggregated protease-resistant prion protein (PrPres) is found in brain as amyloid, which can cause cerebral amyloid angiopathy. Small diffusible precursorsExpand
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Mechanism of Fibronectin Binding to Human Trabecular Meshwork Exosomes and Its Modulation by Dexamethasone
Exosomes are emerging as important mediators of cell-matrix interactions by means of specific adhesion proteins. Changes in the tissue-specific exosomal protein expression may underlie pathologicalExpand
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Effect of Anti-C5a Therapy in a Murine Model of Early/Intermediate Dry Age-Related Macular Degeneration
Purpose A large body of evidence supports a central role for complement activation in the pathobiology of age-related macular degeneration (AMD), including plasma complement component 5a (C5a).Expand
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