Mika Yasui

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Analgesic potencies of relatively selective agonists for mu, delta and kappa subtypes of opioid receptors, morphine, [D-Ala2,D-Leu5]-enkephalin (DADL) and ethylketocyclazocine (EKC), respectively, were examined with the tail-pinch test in the rat, when microinjected into the brain stem regions relevant to analgesia such as the nucleus reticularis(More)
The effects of benzodiazepine inverse agonists on the long-term potentiation of synaptic transmission in hippocampal slices of the guinea pig were examined using an extracellular recording technique. Benzodiazepine inverse agonists, beta-carboline-3-carboxylate (beta-CCE), 2-phenylpyrazolo [4,3-c]quinolin-3(5H)-one (CGS-8216) and(More)
Vulnerability of CA1 pyramidal neurons to hypoxic and hypoglycemic insult was compared in hippocampal slices between the stroke-prone spontaneously hypertensive rat (SHRSP) and its mother strain, Wistar Kyoto rat (WKY). Stimulation of Schaffer collateral-commissural fibers induced D-2-amino-5-phosphonovalerate sensitive multi-component population spikes in(More)
Effects of cholecystokinin octapeptide (CCK-8) on long-term potentiation (LTP) of CA1 synaptic transmission induced by tetanic stimulation of the input fibers were examined in guinea pig hippocampal slices. CCK-8 and a selective agonist for the CCKB receptor, non-sulfated CCK-8, dose-dependently augmented the magnitude of LTP. Concomitant application of a(More)
1. Pharmacological actions of a novel benzodiazepine receptor ligand, S-8510 (2-(3-isoxazolyl)-3,6,7,9-tetrahydroimidazo[4,5-d]pyrano+ ++[4,3-b] pyridine monophosphate monohydrate), were examined in in vitro and in vivo studies. 2. S-8510 was characterized as a partial inverse agonist with a modest GABA ratio and low efficacy. 3. S-8510 ameliorated memory(More)
Prostaglandin E2 plays important roles in the maintenance of colonic homeostasis. The recently identified prostaglandin E receptor (EP) 4-associated protein (EPRAP) is essential for an anti-inflammatory function of EP4 signaling in macrophages in vitro. To investigate the in vivo roles of EPRAP, we examined the effects of EPRAP on colitis and(More)
With increasing body weight, macrophages accumulate in adipose tissue. There, activated macrophages secrete numerous proinflammatory cytokines and chemokines, giving rise to chronic inflammation and insulin resistance. Prostaglandin E2 suppresses macrophage activation via EP4; however, the role of EP4 signaling in insulin resistance and type 2 diabetes(More)
We examined the effect of cholecystokinin octapeptide sulfated type (CCK-8S) on dysfunction of CA1 pyramidal neurons induced by in vitro ischemic insult in hippocampal slices of stroke-prone spontaneously hypertensive rats (SHRSP). CCK-8S shortened the time required for partial recovery from block of a population spike produced by ischemia. Furthermore,(More)
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