Mika Mihori

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To clarify the structure-function relationship (SFR) of vitamin D analogs in terms of their interaction with the vitamin D receptor (VDR), we have proposed a new approach, two-dimensional alanine scanning mutational analysis (2D-ASMA). In this paper, attention was focused on the interactions around the A-ring of vitamin D. For this purpose, we synthesized(More)
PURPOSE To validate the proposed optical requirements of a draft international standard for intraocular lenses (IOLs). SETTING Eight optical testing laboratories in the United States, Germany, Japan, and The Netherlands. METHODS The testing laboratories performed modulation transfer function (MTF) tests on various IOLs using a model eye and visual(More)
Although the stimulations of renal hypertrophy and renal erythropoietin production have been well-known androgen effects in the kidney, recent investigative progresses are further providing good evidences for androgen-regulated gene productions of key enzymes or local hormone substrates important to renal cell metabolisms and tubular functions in mouse or(More)
PURPOSE To describe a testing program conducted by a standards group as a guide for setting international tolerances for intraocular lens (IOL) dioptric power. SETTING Multicenter study. METHODS Seven biconvex, poly(methyl methacrylate) IOLs ranging in power from 10.00 through 30.00 diopter (D) were circulated among nine participating laboratories(More)
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