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Quetiapine, an atypical neuroleptic, has beneficial antipsychotic effects in schizophrenic patients, but with a lower incidence of extrapyramidal symptoms (EPS) compared with typical antipsychotics. While typical antipsychotics are often switched to atypical agents when adverse effects become limiting, there is little preclinical information to support this(More)
Adenosine A1 receptors in the brain are believed to play an important role in brain functioning. We have discovered a novel adenosine A1 receptor antagonist, FR194921 (2-(1-methyl-4-piperidinyl)-6-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3(2H)-pyridazinone), and characterized the pharmacological activity in the present study. FR194921 showed potent and(More)
Amatoxins, including aand b-amanitins, are highly toxic cyclic octapeptide compounds belonging to the Amanita species; these toxins exert gastroenteric symptoms in the early stage, and lead to hepatic failure and renal damage by inhibiting RNA polymerase activity in hepatocytes [1–3]. The Amanita species are considered to be responsible for more than 90 %(More)
One of the key factors of the complete solution for forensic toxicology screening is automation of the library searching with the advanced capability to dynamically review the acquired data. Solutions need to be accurate and robust. The ability to search multiple libraries, create subsets of libraries, adjust and refine search parameters as well as(More)
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